학술논문
Genetic causal relationship between immune diseases and migraine: a Mendelian randomization study
Document Type
article
Author
Guanglu Li; Shaojie Duan; International Headache Genetics Consortium (IHGC); Tao Zheng; Tiantian Zhu; Baoquan Qu; Lei Liu; Zunjing Liu; Verneri Anttila; Ville Artto; Andrea C Belin; Anna Bjornsdottir; Gyda Bjornsdottir; Dorret I Boomsma; Sigrid Børte; Mona A Chalmer; Daniel I Chasman; Bru Cormand; Ester Cuenca-Leon; George Davey-Smith; Irene de Boer; Martin Dichgans; Tonu Esko; Tobias Freilinger; Padhraig Gormley; Lyn R Griffiths; Eija Hämäläinen; Thomas F Hansen; Aster VE Harder; Heidi Hautakangas; Marjo Hiekkala; Maria G Hrafnsdottir; M. Arfan Ikram; Marjo-Riitta Järvelin; Risto Kajanne; Mikko Kallela; Jaakko Kaprio; Mari Kaunisto; Lisette JA Kogelman; Espen S Kristoffersen; Christian Kubisch; Mitja Kurki; Tobias Kurth; Lenore Launer; Terho Lehtimäki; Davor Lessel; Lannie Ligthart; Sigurdur H Magnusson; Rainer Malik; Bertram Müller-Myhsok; Carrie Northover; Dale R Nyholt; Jes Olesen; Aarno Palotie; Priit Palta; Linda M Pedersen; Nancy Pedersen; Matti Pirinen; Danielle Posthuma; Patricia Pozo-Rosich; Alice Pressman; Olli Raitakari; Caroline Ran; Gudrun R Sigurdardottir; Hreinn Stefansson; Kari Stefansson; Olafur A Sveinsson; Gisela M Terwindt; Thorgeir E Thorgeirsson; Arn MJM vanden Maagdenberg; Cornelia van Duijn; Maija Wessman; Bendik S Winsvold; John-Anker Zwart.
Source
Frontiers in Immunology, Vol 15 (2024)
Subject
Language
English
ISSN
1664-3224
Abstract
BackgroundMigraine has an increased prevalence in several immune disorders, but genetic cause-effect relationships remain unclear. Mendelian randomization (MR) was used in this study to explore whether immune diseases are causally associated with migraine and its subtypes.MethodsWe conducted a two-sample bidirectional multivariate Mendelian randomization study. Single-nucleotide polymorphisms (SNP) for six immune diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), type 1 diabetes mellitus (T1D), allergic rhinitis (AR), asthma and psoriasis, were used as genetic instrumental variables. Summary statistics for migraine were obtained from 3 databases: the International Headache Genetics Consortium (IHGC), UK Biobank, and FinnGen study. MR analyses were performed per outcome database for each exposure and subsequently meta-analyzed. Reverse MR analysis was performed to determine whether migraine were risk factors for immune diseases. In addition, we conducted a genetic correlation to identify shared genetic variants for these two associations.ResultsNo significant causal relationship was found between immune diseases and migraine and its subtypes. These results were robust with a series of sensitivity analyses. Using the linkage disequilibrium score regression method (LDSC), we detected no genetic correlation between migraine and immune diseases.ConclusionThe evidence from our study does not support a causal relationship between immune diseases and migraine. The mechanisms underlying the frequent comorbidity of migraine and several immune diseases need to be further elucidated.