학술논문
Blood Gene Expression Predicts Bronchiolitis Obliterans Syndrome
Document Type
article
Author
Richard Danger; Pierre-Joseph Royer; Damien Reboulleau; Eugénie Durand; Jennifer Loy; Adrien Tissot; Philippe Lacoste; Antoine Roux; Martine Reynaud-Gaubert; Carine Gomez; Romain Kessler; Sacha Mussot; Claire Dromer; Olivier Brugière; Jean-François Mornex; Romain Guillemain; Marcel Dahan; Christiane Knoop; Karine Botturi; Aurore Foureau; Christophe Pison; Angela Koutsokera; Laurent P. Nicod; Sophie Brouard; Antoine Magnan; The COLT and SysCLAD Consortia; J. Jougon; J.-F. Velly; H. Rozé; E. Blanchard; C. Dromer; M. Antoine; M. Cappello; R. Souilamas; M. Ruiz; Y. Sokolow; F. Vanden Eynden; G. Van Nooten; L. Barvais; J. Berré; S. Brimioulle; D. De Backer; J. Créteur; E. Engelman; I. Huybrechts; B. Ickx; T. J. C. Preiser; T. Tuna; L. Van Obberghe; N. Vancutsem; J.-L. Vincent; P. De Vuyst; I. Etienne; F. Féry; F. Jacobs; C. Knoop; J. L. Vachiéry; P. Van den Borne; I. Wellemans; G. Amand; L. Collignon; M. Giroux; E. Arnaud-Crozat; V. Bach; P.-Y. Brichon; P. Chaffanjon; O. Chavanon; A. de Lambert; J. P. Fleury; S. Guigard; K. Hireche; A. Pirvu; P. Porcu; R. Hacini; P. Albaladejo; C. Allègre; A. Bataillard; D. Bedague; E. Briot; M. Casez-Brasseur; D. Colas; G. Dessertaine; M. Durand; G. Francony; A. Hebrard; M. R. Marino; B. Oummahan; D. Protar; D. Rehm; S. Robin; M. Rossi-Blancher; P. Bedouch; A. Boignard; H. Bouvaist; A. Briault; B. Camara; S. Chanoine; M. Dubuc; S. Lantuéjoul; S. Quétant; J. Maurizi; P. Pavèse; C. Pison; C. Saint-Raymond; N. Wion; C. Chérion; R. Grima; O. Jegaden; J.-M. Maury; F. Tronc; C. Flamens; S. Paulus; J. F. Mornex; F. Philit; A. Senechal; J.-C. Glérant; S. Turquier; D. Gamondes; L. Chalabresse; F. Thivolet-Bejui; C. Barnel; C. Dubois; A. Tiberghien; F. Le Pimpec-Barthes; A. Bel; P. Mordant; P. Achouh; V. Boussaud; R. Guillemain; D. Méléard; M. O. Bricourt; B. Cholley; V. Pezella; M. Adda; M. Badier; F. Bregeon; B. Coltey; X. B. D’Journo; S. Dizier; C. Doddoli; N. Dufeu; H. Dutau; J. M. Forel; J. Y. Gaubert; C. Gomez; M. Leone; A. Nieves; B. Orsini; L. Papazian; L. C. Picard; M. Reynaud-Gaubert; A. Roch; J. M. Rolain; E. Sampol; V. Secq; P. Thomas; D. Trousse; M. Yahyaoui; O. Baron; P. Lacoste; C. Perigaud; J. C. Roussel; I. Danner; A. Haloun; A. Magnan; A. Tissot; T. Lepoivre; M. Treilhaud; K. Botturi-Cavaillès; S. Brouard; R. Danger; J. Loy; M. Morisset; M. Pain; S. Pares; D. Reboulleau; P. J. Royer; E. Durand; A. Foureau; Ph. Dartevelle; D. Fabre; E. Fadel; O. Mercier; S. Mussot; F. Stephan; P. Viard; J. Cerrina; P. Dorfmuller; S. Feuillet; M. Ghigna; Ph. Hervén; F. Le Roy Ladurie; J. Le Pavec; V. Thomas de Montpreville; L. Lamrani; Y. Castier; P. Cerceau; F. Francis; G. Lesèche; N. Allou; P. Augustin; S. Boudinet; M. Desmard; G. Dufour; P. Montravers; O. Brugière; G. Dauriat; G. Jébrak; H. Mal; A. Marceau; A.-C. Métivier; G. Thabut; B. Ait Ilalne; P. Falcoz; G. Massard; N. Santelmo; G. Ajob; O. Collange; O. Helms; J. Hentz; A. Roche; B. Bakouboula; T. Degot; A. Dory; S. Hirschi; S. Ohlmann-Caillard; L. Kessler; R. Kessler; A. Schuller; K. Bennedif; S. Vargas; P. Bonnette; A. Chapelier; P. Puyo; E. Sage; J. Bresson; V. Caille; C. Cerf; J. Devaquet; V. Dumans-Nizard; M. L. Felten; M. Fischler; A. G. Si Larbi; M. Leguen; L. Ley; N. Liu; G. Trebbia; S. De Miranda; B. Douvry; F. Gonin; D. Grenet; A. M. Hamid; H. Neveu; F. Parquin; C. Picard; A. Roux; M. Stern; F. Bouillioud; P. Cahen; M. Colombat; C. Dautricourt; M. Delahousse; B. D’Urso; J. Gravisse; A. Guth; S. Hillaire; P. Honderlick; M. Lequintrec; E. Longchampt; F. Mellot; A. Scherrer; L. Temagoult; L. Tricot; M. Vasse; C. Veyrie; L. Zemoura; J. Berjaud; L. Brouchet; M. Dahan; F. Le Balle; O. Mathe; H. Benahoua; A. Didier; A. L. Goin; M. Murris; L. Crognier; O. Fourcade; T. Krueger; H. B. Ris; M. Gonzalez; J.-D. Aubert; L. P. Nicod; B. J. Marsland; T. C. Berutto; T. Rochat; P. Soccal; Ph. Jolliet; A. Koutsokera; C. Marcucci; O. Manuel; E. Bernasconi; M. Chollet; F. Gronchi; C. Courbon; Zurich S. Hillinger; I. Inci; P. Kestenholz; W. Weder; R. Schuepbach; M. Zalunardo; C. Benden; U. Buergi; L. C. Huber; B. Isenring; M. M. Schuurmans; A. Gaspert; D. Holzmann; N. Müller; C. Schmid; B. Vrugt; T. Rechsteiner; A. Fritz; D. Maier; K. Desplanche; D. Koubi; F. Ernst; T. Paprotka; M. Schmitt; B. Wahl; J.-P. Boissel; G. Olivera-Botello; C. Trocmé; B. Toussaint; S. Bourgoin-Voillard; M. Séve; M. Benmerad; V. Siroux; R. Slama; C. Auffray; D. Charron; J. Pellet
Source
Frontiers in Immunology, Vol 8 (2018)
Subject
Language
English
ISSN
1664-3224
Abstract
Bronchiolitis obliterans syndrome (BOS), the main manifestation of chronic lung allograft dysfunction, leads to poor long-term survival after lung transplantation. Identifying predictors of BOS is essential to prevent the progression of dysfunction before irreversible damage occurs. By using a large set of 107 samples from lung recipients, we performed microarray gene expression profiling of whole blood to identify early biomarkers of BOS, including samples from 49 patients with stable function for at least 3 years, 32 samples collected at least 6 months before BOS diagnosis (prediction group), and 26 samples at or after BOS diagnosis (diagnosis group). An independent set from 25 lung recipients was used for validation by quantitative PCR (13 stables, 11 in the prediction group, and 8 in the diagnosis group). We identified 50 transcripts differentially expressed between stable and BOS recipients. Three genes, namely POU class 2 associating factor 1 (POU2AF1), T-cell leukemia/lymphoma protein 1A (TCL1A), and B cell lymphocyte kinase, were validated as predictive biomarkers of BOS more than 6 months before diagnosis, with areas under the curve of 0.83, 0.77, and 0.78 respectively. These genes allow stratification based on BOS risk (log-rank test p