학술논문
Temporal Airy pulses control cell poration
Document Type
article
Author
Source
APL Photonics, Vol 1, Iss 4, Pp 046102-046102-7 (2016)
Subject
Language
English
ISSN
2378-0967
Abstract
We show that spectral phase shaping of fs-laser pulses can be used to optimize laser-cell membrane interactions in water environment. The energy and peak intensity thresholds required for cell poration with single pulse in the nJ range can be significantly reduced (25% reduction in energy and 88% reduction in peak intensity) by using temporal Airy pulses, controlled by positive third order dispersion, as compared to bandwidth limited pulses. Temporal Airy pulses are also effective to control the morphology of the induced pores, with prospective applications from cellular to tissue opto-surgery and transfection.