학술논문
P3.08 C-REACTIVE PROTEIN BUT NOT ADVANCED GLYCATION END-PRODUCTS ARE RELATED TO ALTERED GLUCOSE METABOLISM AND ARTERIAL STIFFENING IN THE MIDDLE AGED METABOLIC SYNDROME SUBJECTS: DATA FROM A CROSS SECTIONAL STUDY
Document Type
article
Source
Artery Research, Vol 7, Iss 10 (2013)
Subject
Language
English
ISSN
1876-4401
Abstract
Objectives: The aim of our study was to investigate the relationship between glucose metabolism, high sensitivity C-reactive protein (hsCRP), advanced glycation end-products (AGEs) and aortic stiffness in non-diabetic middle aged metabolic syndrome (MetS) subjects. Methods: We studied a total of 486 non-diabetic subjects (aged 40–65, 61% women) with MetS but without overt atherosclerotic disease. AGEs were measured by skin autofluorescence while aortic stiffness was assessed as carotid to femoral pulse wave velocity (PWV) by applanation tonometry. Glucose metabolism was evaluated by oral glucose tolerance test. Results: In univariate analysis, log transformed hsCRP were significantly associated with various indices of insulin resistance (rHOMA-IR =0.20, rQUICKI =−0.20, p