학술논문
Genome-wide transcriptional profiling of pulmonary functional sequelae in ARDS- secondary to SARS-CoV-2 infection
Document Type
article
Author
María C. García-Hidalgo; Rafael Peláez; Jessica González; Sally Santisteve; Iván D. Benítez; Marta Molinero; Manel Perez-Pons; Thalía Belmonte; Gerard Torres; Anna Moncusí-Moix; Clara Gort-Paniello; Maria Aguilà; Faty Seck; Paola Carmona; Jesús Caballero; Carme Barberà; Adrián Ceccato; Laia Fernández-Barat; Ricard Ferrer; Dario Garcia-Gasulla; Jose Ángel Lorente-Balanza; Rosario Menéndez; Ana Motos; Oscar Peñuelas; Jordi Riera; Jesús F. Bermejo-Martin; Antoni Torres; Ferran Barbé; David de Gonzalo-Calvo; Ignacio M. Larráyoz
Source
Biomedicine & Pharmacotherapy, Vol 154, Iss , Pp 113617- (2022)
Subject
Language
English
ISSN
0753-3322
Abstract
Background: Up to 80% of patients surviving acute respiratory distress syndrome (ARDS) secondary to SARS-CoV-2 infection present persistent anomalies in pulmonary function after hospital discharge. There is a limited understanding of the mechanistic pathways linked to post-acute pulmonary sequelae. Aim: To identify the molecular underpinnings associated with severe lung diffusion involvement in survivors of SARS-CoV-2-induced ARDS. Methods: Survivors attended to a complete pulmonary evaluation 3 months after hospital discharge. RNA sequencing (RNA-seq) was performed using Illumina technology in whole-blood samples from 50 patients with moderate to severe diffusion impairment (DLCO