학술논문
Kidney transplantation of 32 patients from HLA-incompatible live donors: Efficacy and outcome after desensitization
Document Type
article
Author
Source
Nefrología (English Edition), Vol 37, Iss 6, Pp 638-645 (2017)
Subject
Language
English
ISSN
2013-2514
Abstract
Desensitization is a procedure undergone by the recipient of a kidney transplant from a donor who is cross-match positive. The aim of this study was to present the outcomes from our hospital of kidney transplant recipients from HLA-incompatible live donors after desensitization.We studied 32 patients aged 46 ± 14 years with a mean fluorescence intensity (MFI) versus class I HLA of 7979 ± 4089 and 6825 ± 4182 MFI versus class II and relative intensity scale (RIS) of 8.9 ± 7.6. The complement-dependent cytotoxicity (CDC) cross-matching test was positive in 18 patients, flow cytometry was positive in 7 patients and donor-specific antibodies (DEA) were detected in 7. The protocol used was rituximab, plasmapheresis/immunoadsorption, immunoglobulins, tacrolimus, mycophenolic acid derivatives and prednisone.After 8 ± 3 sessions of plasmapheresis/immunoadsorption, 23 patients were transplanted (71.9%) and desensitization was ineffective in 9. There were baseline differences in MFI class I (p