학술논문
Exercise and Prediabetes After Renal Transplantation (EXPRED-I): A Prospective Study
Document Type
article
Author
Raúl Morales Febles; Domingo Marrero Miranda; Alejandro Jiménez Sosa; Ana González Rinne; Coriolano Cruz Perera; Ana Elena Rodríguez-Rodríguez; Alejandra Álvarez González; Laura Díaz Martín; Natalia Negrín Mena; Cristian Acosta Sørensen; Lourdes Pérez Tamajón; Aurelio Rodríguez Hernández; Federico González Rinne; Aday Dorta González; Eusebio Ledesma Pérez; Alejandra González Delgado; Alberto Domínguez-Rodríguez; Maria del Carmen García Baute; Armando Torres Ramírez; Esteban Porrini
Source
Sports Medicine - Open, Vol 9, Iss 1, Pp 1-13 (2023)
Subject
Language
English
ISSN
2198-9761
Abstract
Abstract Background Post-transplant diabetes mellitus (PTDM) beyond 12 months (late PTDM) is a severe complication after renal transplantation. Late PTDM develops mostly in subjects with prediabetes. Although exercise may have a potential role in preventing late PTDM, there are no previous data on the effect of exercise in patients with prediabetes. Material and Methods The design was a 12-month exploratory study to test the capacity of exercise in reverting prediabetes in order to prevent late-PTDM. The outcome was the reversibility of prediabetes, assessed every 3 months with oral glucose tolerance tests (OGTT). The protocol included an incremental plan of aerobic and/or strength training as well as an active plan for promoting adherence (telephone calls, digital technology, and visits). A priori, a sample size cannot be calculated which makes this an exploratory analysis. Based on previous studies, the spontaneous reversibility of prediabetes was 30% and the reversibility induced by exercise will account for another 30%, a total reversibility of 60% (p value