학술논문
Diabetic ketoacidosis in children with new-onset type 1 diabetes mellitus: demographics, risk factors and outcome: an 11 year review in Hong Kong
Document Type
research-article
Author
Poon, Sarah Wing-yiu; Tung, Joanna Yuet-ling; Wong, Wilfred Hing-sang; Cheung, Pik-to; Fu, Antony Chun-cheung; Pang, Gloria Shir-wey; To, Sharon Wing-yan; Wong, Lap-ming; Wong, Wai-yu; Chan, Suk-yan; Yau, Ho-chung; See, Wing-shan; But, Betty Wai-man; Wong, Shirley Man-yee; Lo, Priscilla Wai-chee; Ng, Kwok-leung; Chan, Kwong-tat; Lam, Hi-yuet; Wong, Sammy Wai-chun; Lam, Yuen-yu; Yuen, Hoi-wing; Chung, Jacky Ying-ki; Lee, Ching-yee; Tay, Ming-kut; Kwan, Elaine Yin-wah
Source
Journal of Pediatric Endocrinology and Metabolism. 35(9):1132-1140
Subject
Language
English
ISSN
0334-018X
2191-0251
2191-0251
Abstract
Objectives Diabetic ketoacidosis (DKA) is a life-threatening complication of type 1 diabetes (T1D). The aim of this study is to analyze the incidence, clinical characteristics, management and outcome of children presenting with DKA in new-onset T1D from 2008 to 2018 in Hong Kong. Methods Data was extracted from the Hong Kong Childhood Diabetes Registry. All subjects less than 18 years with newly diagnosed T1D from 1 January 2008 to 31 December 2018 managed in the public hospitals were included. Information on demographics, laboratory parameters, DKA-related complications and management were analyzed. Results In the study period, there were 556 children with newly diagnosed T1D in our registry and 43.3% presented with DKA. The crude incidence rate of new-onset T1D with DKA was 1.79 per 100,000 persons/year (CI: 1.56–2.04). Subjects presenting with DKA were younger (9.5 ± 4.5 vs. 10.5 ± 4.4, p=0.01) and had shorter duration of symptoms (4.2 ± 5.9 days vs. 10.6 ± 17.1 days, p Conclusions Younger age and shorter duration of symptoms were associated with DKA in new-onset T1D. Despite availability of international guidelines, there was inconsistency in acute DKA management. These call for a need to raise public awareness on childhood diabetes as well as standardization of practice in management of pediatric DKA in Hong Kong.