학술논문
Carriage of HLA-DRB1*11 and 1*12 alleles and risk factors in patients with breast cancer in Burkina Faso
Document Type
research-article
Author
Zouré, Abdou Azaque; Amegnona, Lanyo Jospin; Zongo, Nayi; Kiendrebeogo, Isabelle Touwendpoulimdé; Sorgho, Pegdwendé Abel; Zongo, Fabienne Ingrid; Yonli, Albert Théophane; Sombié, Herman Karim; Bambara, Aboubacar Hierrhum; Sawadogo, Alexis Yobi; Ouedraogo, Marie N. L.; Traoré, Lassina; Zongo, Sidnooma Véronique; Lallogo, Doriane Tatiana; Bazié, Bapio Valery Jean Télesphore Elvira; Zohoncon, Théodora M.; Dijgma, Florencia W.; Simpore, Jacques
Source
Open Life Sciences. 16(1):1101-1110
Subject
Language
English
ISSN
2391-5412
Abstract
Several factors contribute to the development of breast cancer, including the immune system. This study is aimed to characterize the carriage of human leukocyte antigen (HLA)-DRB1*11 and 1*12 alleles in patients with breast cancer. This case-control study consisted of 96 histologically diagnosed breast cancer cases and 102 controls (cases without breast abnormalities). A multiplex polymerase chain reaction (PCR) was used to characterize the carriage of HLA-DRB1*11 and 1*12 alleles. The HLA-DRB1*11 allele was present in 26.59% of cases and 22.55% of controls. The HLA-DRB1*12 allele was present in 56.63% of cases and 55.88% of controls. This study found no direct association between the carriage of the HLA-DRB1*11 and HLA-DRB1*12 alleles and the occurrence of breast cancer. In addition, the deletion of the HLA-DRB1*11 allele is associated (beneficial effect) with obesity/overweight (OR = 0.13; 95% CI [0.01–1.14]; and p = 0.03) which is a risk for breast cancer. No direct association was found between the carriage of HLA-DRB1*11 and 1*12 alleles and breast cancer risk. However, further investigation of other HLA alleles involved in the occurrence of breast cancer may provide more information.