학술논문
Numerical investigation of diagnostic properties of p53-dependent microRNAs
Document Type
research-article
Source
Russian Journal of Numerical Analysis and Mathematical Modelling. 32(3):203-213
Subject
Language
English
ISSN
1569-3988
0927-6467
0927-6467
Abstract
In the present paper we propose a mathematical model and study numerically the functioning of the p53 tumors suppressor protein and the direct positive connection of microRNA molecules related to it. The adequacy of the model is confirmed by qualitative concordance of calculation results with the experimental data concerning transactivation of specific p53-dependent microRNAs. Estimates of stability of individual and p53-mediated properties of microRNA as factors in diagnosing cancer and neurodegenerative diseases are given within the framework of the accepted model.