학술논문
肌萎缩侧索硬化症个案处方用药规律挖掘 / Exploration of Prescription Medication Rules in Case Reports of Amyotrophic Lateral Sclerosis
Document Type
Academic Journal
Source
中国药业 / China Pharmaceuticals. 33(4):53-57
Subject
Language
Chinese
ISSN
1006-4931
Abstract
目的 为中医临床治疗肌萎缩侧索硬化症(ALS)提供参考.方法 计算机检索中国知网中以中药治疗ALS的个案文献,检索时限为自建库起至 2022 年 11 月.采用Excel软件统计复方中组方药物的使用频次(率)、四气(性)、五味、归经、功效,并导入中医传承计算平台(V3.0)进行数据挖掘.结果 共纳入个案文献 110 篇,涉及中药组方 139 个、中药 218 味,累计使用频次 1 946 次.常用药物(使用频率>10%)45 味,性味归经分别以温性(47.35%)、甘味(42.45%)、归脾经(20.29%)为主,药物功效以补虚类(41.37%)为主.中药组合 98 个,涉及中药 24 味,其中以黄芪、白术、党参组合(33 次)最常见,药对以黄芪-山药、黄芪-熟地黄最常见(均使用 32 次);聚类分析提取核心药物组合 5 类.结论 ALS个案用药处方以补虚类中药为核心,分补气、补血、补阳、补肝肾,配以升阳、温里、行气等药味.处方组合以气血双补、阴阳双补、清热化痰和益气活血为主要功效.
Objective To provide a reference for the clinical treatment of amyotrophic lateral sclerosis(ALS)with traditional Chinese medicine.Methods Case reports of Chinese materia medica in the treatment of ALS in the CNKI from the inception of this database to November 2022 were searched.The medicinal frequency of use,nature,flavor,meridian returned and efficacy in prescriptions were recorded by the Excel software and imported into the Traditional Chinese Medicine Inheritance Computer System(V 3.0)for data mining.Results A total of 110 case reports were included,involving 139 prescriptions and 218 Chinese materia medicas,with the cumulative use frequency of 1 946 times.Forty-five Chinese materia medicas were commonly used,with a frequency of use>10%,the nature,flavor and meridian returned was mainly warm(47.35%),sweet(42.45%)and spleen meridian(20.29%),and the efficacy was mainly tonifying deficiency(41.37%).There were 98 drug combinations,involving 24 Chinese materia medicas,mainly Astragali Radix-Atractylodis Macrocephalae Rhizoma-Codonopsis Radix(33 times),with the main drug pairs of Astragali Radix-Dioscoreae Rhizoma(32 times)and Astragali Radix-Rehmanniae Radix Praeparata(32 times).The cluster analysis showed that five core drug combinations were extracted.Conclusion The deficiency-tonifying drugs are the core in the medication prescriptions for ALS in case reports,including Qi-,blood-,Yang-,liver-and kidney-tonifying drugs,and they are supplemented with Yang-lifting,interior-warming and Qi-moving drugs.The prescription combination are mainly based on the principles of tonifying Qi and blood,tonifying Yin and Yang,clearing heat and dissipating phlegm,and benefiting Qi and activating blood.
Objective To provide a reference for the clinical treatment of amyotrophic lateral sclerosis(ALS)with traditional Chinese medicine.Methods Case reports of Chinese materia medica in the treatment of ALS in the CNKI from the inception of this database to November 2022 were searched.The medicinal frequency of use,nature,flavor,meridian returned and efficacy in prescriptions were recorded by the Excel software and imported into the Traditional Chinese Medicine Inheritance Computer System(V 3.0)for data mining.Results A total of 110 case reports were included,involving 139 prescriptions and 218 Chinese materia medicas,with the cumulative use frequency of 1 946 times.Forty-five Chinese materia medicas were commonly used,with a frequency of use>10%,the nature,flavor and meridian returned was mainly warm(47.35%),sweet(42.45%)and spleen meridian(20.29%),and the efficacy was mainly tonifying deficiency(41.37%).There were 98 drug combinations,involving 24 Chinese materia medicas,mainly Astragali Radix-Atractylodis Macrocephalae Rhizoma-Codonopsis Radix(33 times),with the main drug pairs of Astragali Radix-Dioscoreae Rhizoma(32 times)and Astragali Radix-Rehmanniae Radix Praeparata(32 times).The cluster analysis showed that five core drug combinations were extracted.Conclusion The deficiency-tonifying drugs are the core in the medication prescriptions for ALS in case reports,including Qi-,blood-,Yang-,liver-and kidney-tonifying drugs,and they are supplemented with Yang-lifting,interior-warming and Qi-moving drugs.The prescription combination are mainly based on the principles of tonifying Qi and blood,tonifying Yin and Yang,clearing heat and dissipating phlegm,and benefiting Qi and activating blood.