학술논문
康复新液治疗口腔正畸患儿慢性牙龈炎的临床效果分析 / Analysis of the clinical effect of Kangfuxin Liquid in the treatment of chronic gingivitis in orthodontic patients
Document Type
Academic Journal
Author
Source
中国基层医药 / Chinese Journal of Primary Medicine and Pharmacy. 25(19):2471-2474
Subject
Language
Chinese
ISSN
1008-6706
Abstract
目的 探讨康复新液治疗口腔正畸患儿慢性牙龈炎的临床效果.方法 2014年1月至2016年2月,选取100例在浙江绿城心血管病医院口腔科接受口腔正畸治疗后出现慢性牙龈炎的患儿作为研究对象,采取计算机数列随机分组方法将患儿分为对照组与观察组,每组50例.对照组患儿接受口腔洁治术,观察组患儿在口腔洁治术基础上加用康复新液进行治疗,比较两组临床疗效、菌斑指数、龈沟出血指数、疼痛评分、肿胀评分、龈沟液炎性因子水平.结果 相比于对照组的82％,观察组临床治疗总有效率(96％)更高(χ2=5.005,P<0.05).两组治疗后菌斑指数、龈沟出血指数、疼痛评分、肿胀评分均明显低于治疗前(均P<0.05),而在治疗后,观察组菌斑指数(1.14±0.36)分、龈沟出血指数(1.96±0.64)分、疼痛评分(2.94±0.96)分、肿胀评分(3.32±0.97)分均明显低于对照组(t=4.862、5.041、5.513、4.923,均P<0.05).两组治疗后龈沟液中白细胞介素-1β(IL-1β)、前列腺素E2(PGE2)、可溶性黏附分子-1(sICAM-1)均较治疗前明显降低(P均<0.05),而在治疗后,观察组的IL-1β(10.32±1.19)ng/L、PGE2(246.53±36.29)ng/L、sICAM-1(135.23±14.32)μg/L,均低于对照组(t=4.973、5.211、5.144,均P<0.05).结论 采用康复新液对口腔正畸后慢性牙龈炎患儿进行治疗具有显著的临床疗效,可有效减轻患者的牙周炎症、牙龈疼痛及肿胀情况,还可对龈沟液中的炎性因子予以有效抑制,有利于改善预后.
Objective To study the clinical effect of Kangfuxin Liquid in the treatment of orthodontic children with chronic gingivitis.Methods From January 2014 to February 2016,a total of 100 orthodontic children with chronic gingivitis in Zhejiang Greentown Cardiovascular Hospital were selected in the research.The patients were randomly divided into the control group and observation group according to the computer numeral list method,with 50 cases in each group.The control group was treated with oral scaling,children in the observation group were treated with Kangfuxin Liquid on the basis of oral scaling.The clinical curative effect,plaque index,sulcus bleeding index,pain score,swelling score,the levels of inflammatory cytokines in gingival crevicular fluid were compared between the two groups.Results The total effective rate of the observation group was 96％,which was higher than 82％of the control group(χ2 =5.005,P<0.05).After treatment,the plaque index,gingival sulcus bleeding index,pain score,swelling scores in the two groups were significantly lower than those before treatment(all P<0.05).After treatment,the plaque index,gingival sulcus bleeding index,pain score,swelling score in the observation group were(1.14 ± 0.36)points,(1.96 ±0.64)points,(2.94 ±0.96)points,(3.32 ±0.97)points,respectively,which were significantly lower than those in the control group(t=4.862,5.041,5.513,5.041,all P<0.05).After treatment,the interleukin 1 beta(IL-1 beta),prostaglandin E2(PGE2),soluble adhesion molecule 1(sICAM-1)of gingival sulcus fluid in the two groups were significantly lower than those before treatment(all P<0.05),while after treatment,the levels of IL-1 beta,PGE2 sICAM-1 in the observation group were(10.32 ±1.19)ng/L,(246.53 ±36.29)ng/L,(135.23 ± 14.32)μg/L,respectively,which were lower than those in the control group(t=4.973,5.211,4.973,all P<0.05).Conclusion The use of Kangfuxin Liquid on chronic gingivitis after orthodontic treatment has significant clinical efficacy,can effectively reduce periodontal inflammation in patients with gingival swelling and pain,and can effectively inhibit inflammatory cytokines in gingival crevicular fluid,and improve the prognosis.
Objective To study the clinical effect of Kangfuxin Liquid in the treatment of orthodontic children with chronic gingivitis.Methods From January 2014 to February 2016,a total of 100 orthodontic children with chronic gingivitis in Zhejiang Greentown Cardiovascular Hospital were selected in the research.The patients were randomly divided into the control group and observation group according to the computer numeral list method,with 50 cases in each group.The control group was treated with oral scaling,children in the observation group were treated with Kangfuxin Liquid on the basis of oral scaling.The clinical curative effect,plaque index,sulcus bleeding index,pain score,swelling score,the levels of inflammatory cytokines in gingival crevicular fluid were compared between the two groups.Results The total effective rate of the observation group was 96％,which was higher than 82％of the control group(χ2 =5.005,P<0.05).After treatment,the plaque index,gingival sulcus bleeding index,pain score,swelling scores in the two groups were significantly lower than those before treatment(all P<0.05).After treatment,the plaque index,gingival sulcus bleeding index,pain score,swelling score in the observation group were(1.14 ± 0.36)points,(1.96 ±0.64)points,(2.94 ±0.96)points,(3.32 ±0.97)points,respectively,which were significantly lower than those in the control group(t=4.862,5.041,5.513,5.041,all P<0.05).After treatment,the interleukin 1 beta(IL-1 beta),prostaglandin E2(PGE2),soluble adhesion molecule 1(sICAM-1)of gingival sulcus fluid in the two groups were significantly lower than those before treatment(all P<0.05),while after treatment,the levels of IL-1 beta,PGE2 sICAM-1 in the observation group were(10.32 ±1.19)ng/L,(246.53 ±36.29)ng/L,(135.23 ± 14.32)μg/L,respectively,which were lower than those in the control group(t=4.973,5.211,4.973,all P<0.05).Conclusion The use of Kangfuxin Liquid on chronic gingivitis after orthodontic treatment has significant clinical efficacy,can effectively reduce periodontal inflammation in patients with gingival swelling and pain,and can effectively inhibit inflammatory cytokines in gingival crevicular fluid,and improve the prognosis.