학술논문
免疫指标在结核性胸腔积液诊断中的研究进展 / Advances in immune markers research for tuberculous pleural effusion diagnosis
Document Type
Academic Journal
Source
西部医学 / Medical Journal of West China. 36(1):152-156
Subject
Language
Chinese
ISSN
1672-3511
Abstract
结核性胸腔积液是结核病高发地区常见的胸腔积液病因,特定生物标志物检测有助于对结核性胸腔积液的快速诊断.结核病的病理生理学在很大程度上是一种免疫反应,与大量的细胞因子和趋化因子密切相关.在胸腔积液中寻找能够指示结核性胸腔积液(TPE)进程和免疫状态的分子标志物是近年研究的热点,其中重点以干扰素γ、白细胞介素家族等细胞因子为代表.一些学者也提出了新的具有前景的诊断方法,但需要更多的基础研究和临床研究进行验证.本文就用于结核性胸腔积液诊断方面的免疫标志物、新的诊断方法进展做一综述,以供临床实践及未来诊断新技术的开发参考与借鉴.
Tuberculous pleural effusion is a common cause of pleural effusion in areas with high incidence of tuber-culosis.The detection of specific biomarkers is helpful for the rapid diagnosis of tuberculous pleural effusion.The patho-physiology of tuberculosis is to a large extent an immune response,which is closely related to a large number of cytokines and chemokines.Searching for molecular markers that can indicate TPE progression and immune status in pleural effu-sion is a hot topic in recent years,which is represented by cytokines such as interferon-γ and interleukin family.Some scholars have also proposed new promising diagnostic methods,but more basic research and clinical research are needed to verify them.This article reviews the progress of immune markers and new diagnostic methods in the diagnosis of tu-berculous pleural effusion,which can be used as a reference for clinical practice and the development of new diagnostic techniques in the future.
Tuberculous pleural effusion is a common cause of pleural effusion in areas with high incidence of tuber-culosis.The detection of specific biomarkers is helpful for the rapid diagnosis of tuberculous pleural effusion.The patho-physiology of tuberculosis is to a large extent an immune response,which is closely related to a large number of cytokines and chemokines.Searching for molecular markers that can indicate TPE progression and immune status in pleural effu-sion is a hot topic in recent years,which is represented by cytokines such as interferon-γ and interleukin family.Some scholars have also proposed new promising diagnostic methods,but more basic research and clinical research are needed to verify them.This article reviews the progress of immune markers and new diagnostic methods in the diagnosis of tu-berculous pleural effusion,which can be used as a reference for clinical practice and the development of new diagnostic techniques in the future.