학술논문
Phthalide-derived oxaspiroangelioic acids A-C with an unprecedented carbon skeleton from an aqueous extract of the Angelica sinensis root head
Document Type
Academic Journal
Source
中国化学快报（英文版） / Chinese Chemical Letters. 32(10):3257-3260
Subject
Language
Chinese
ISSN
1001-8417
Abstract
Three phthalide-derived analogues,oxaspiroangelioic acids A-C (1-3),were isolated as minor components of an aqueous extract of the Angelica sinensis root heads (guitou).Oxaspiroangelioic acids A and B were racemates separated into enantiomers by chiral HPLC.Their structures including absolute configurations were determined by spectroscopic data analysis,single crystal X-ray diffraction,exciton chirality method and electronic circular dichroism (ECD) calculation.These compounds share an undescribed carbon skeleton,for which biosynthetic pathways are proposed.Compound 1 and its enantiomers showed almost identical activity inhibiting Tandem of P domains in a weak inwardly rectifying K+ channel 1 (TREK-1).