학술논문
不同频率音乐对小鼠空间学习记忆能力的影响 / Impact of music of different frequencies on the spatial learning and memory ability of mice
Document Type
Academic Journal
Author
Source
中国比较医学杂志 / Chinese Journal of Comparative Medicine. 27(9):71-75
Subject
Language
Chinese
ISSN
1671-7856
Abstract
目的 初步探究音乐对成年小鼠学习记忆能力是否产生影响.方法 80只C57小鼠随机分成10组,每组雌雄各半.空白对照组:不给予音乐刺激,高频音乐3组、中频音乐3组、低频音乐3组,分别用高频、中频、低频各3首进行音乐刺激,每天5 h,连续6 d.第7天进行水迷宫测试,期间保持音乐刺激不变,测试指标为潜伏期,经过平台次数和平台象限停留时间.结果 音乐组与空白组相比,小鼠逃避潜伏期明显缩短(P<0.05),经过平台次数和平台象限停留时间虽有增多,但差异无显著性(P>0.05).各音乐组之间检测指标差异无显著性(P>0.05).结论 所选9首音乐能提高成年小鼠学习记忆能力,而不同频率音乐之间产生的影响未发现显著性差异.推测音乐刺激对小鼠的影响与音乐分类的标准、刺激周期长短、刺激时间点选择等因素密切相关.
Objective To explore the impact of music of different frequencies on the spatial learning and memory a?bility of mice. Methods A total of 80 healthy 6～8 weeks old C57 mice were randomly divided into 10 groups, half male and half female in each group. The mice in the control group were not stimulated by music. The mice of the 3 groups of high?frequency music, 3 groups of medium?frequency music and 3 groups of low?frequency music were stimulated by music in cor?responding range of frequency, respectively, for 5 h each day. After 6 d, the ability of spatial learning and memory of the mice was tested in the Morris water maze, with the same stimulation of music during the test. The indicators of the test in?cluded the avoiding latency, the frequency of passing the platform and the time spent to pass the quadrant of the mice in each group. Results Compared with the control group, the avoiding latency of the mice in the groups with stimulation by music was significantly shorter (P< 0. 05). The frequency of passing the platform and the time spent to pass the quadrant were in?creased, yet the difference was not significant (P> 0. 05). Moreover, there was no significant difference between the indica?tors of the 9 groups receiving music stimulation (P> 0. 05). Conclusions The 9 pieces of music we have selected can im?prove the ability of spatial learning and memory in adult mice, however, the effects of the music of different frequencies did not show significant difference. It is hypothesized that the impact of music stimulation on mice may be related to the criteria for music classification, the duration of cycle of music stimulation and the selection of time points of stimulation.
Objective To explore the impact of music of different frequencies on the spatial learning and memory a?bility of mice. Methods A total of 80 healthy 6～8 weeks old C57 mice were randomly divided into 10 groups, half male and half female in each group. The mice in the control group were not stimulated by music. The mice of the 3 groups of high?frequency music, 3 groups of medium?frequency music and 3 groups of low?frequency music were stimulated by music in cor?responding range of frequency, respectively, for 5 h each day. After 6 d, the ability of spatial learning and memory of the mice was tested in the Morris water maze, with the same stimulation of music during the test. The indicators of the test in?cluded the avoiding latency, the frequency of passing the platform and the time spent to pass the quadrant of the mice in each group. Results Compared with the control group, the avoiding latency of the mice in the groups with stimulation by music was significantly shorter (P< 0. 05). The frequency of passing the platform and the time spent to pass the quadrant were in?creased, yet the difference was not significant (P> 0. 05). Moreover, there was no significant difference between the indica?tors of the 9 groups receiving music stimulation (P> 0. 05). Conclusions The 9 pieces of music we have selected can im?prove the ability of spatial learning and memory in adult mice, however, the effects of the music of different frequencies did not show significant difference. It is hypothesized that the impact of music stimulation on mice may be related to the criteria for music classification, the duration of cycle of music stimulation and the selection of time points of stimulation.