학술논문
锡类散栓剂对大鼠宫颈炎治疗作用的实验研究 / Experimental Study on Therapeutic Effects of Xileisan Pessary on Rats with Cervicitis
Document Type
Academic Journal
Author
吴芊; 崔人匀; 托托; 肖伊; 黄羚; 刘豫玥; 刘锦林; 牟天龙; 潘彦舒; WU Qian; CUI Ren-yun; TUO Tuo; XIAO Yi; HUANG Ling; LIU Yu-yue; LIU Jin-lin; MU Tian-long; PAN Yan-shu
Source
中国中医药信息杂志. 23(9):82-86
Subject
Language
Chinese
ISSN
1005-5304
Abstract
目的：基于“异病同治”理论探讨锡类散栓剂对大鼠宫颈炎的治疗作用。方法采用阴道灌注苯酚胶浆制作大鼠宫颈炎模型。实验大鼠随机分为正常组、模型组、阳性药组和锡类散低、中、高剂量组。造模结束后次日锡类散栓剂阴道给药，连续10 d，血常规分析仪检测大鼠血液中性粒细胞数和白细胞总数，HE染色行宫颈病理组织学检查。结果与正常组比较，模型组中性粒细胞数和白细胞总数显著升高（P＜0.01）。与模型组比较，锡类散低剂量组血液中性粒细胞数、白细胞总数显著降低（P＜0.05，P＜0.01），大鼠宫颈黏膜上皮炎症及组织损伤均明显减轻；锡类散中剂量组血液中性粒细胞数有降低趋势（P＞0.05），白细胞总数无明显变化；锡类散高剂量组血液中性粒细胞数显著升高（P＜0.01），白细胞总数有升高趋势（P＞0.05）；阳性药组血液中性粒细胞数和白细胞总数显著降低（P＜0.01），大鼠宫颈黏膜上皮炎症及组织损伤均明显减轻。结论锡类散可减轻大鼠宫颈炎症损伤，修复受损宫颈黏膜，具有异病同治的作用。
Objective To study the therapeutic effects of Xileisan Pessary on rats with cervicitis based on the idea of treating different diseases with the same therapy. Methods Vagina perfusion of hydroxybenzene mucilage was used to establish rat cervicitis models. Rats were randomly divided into normal group, model group, positive medicine group, low-, medium-, and high-dose Xileisan Pessary groups. Rats with cervicitis were treated with Xileisan Pessary from the next day after modeling for 10 days. The amount of neutrophilic granulocytes and leukocytes were detected by blood routine analysis meter; cervial histopathologic examination was conducted by HE staining. Results Compared with normal group, the numbers of granulocyte and leucocyte increased significantly in the model group (P<0.01). Compared with the model group, the numbers of granulocyte and leucocyte in the low-dose Xileisan Pessary group showed a decreasing trend (P<0.05, P<0.01); cervical inflammation mucosal epithelium and tissue necrosis were signally alleviated; granulocyte in the medium-dose Xileisan Pessary group showed a decreasing trend (P>0.05);the content of leucocyte hardly changed;granulocyte in the high-dose Xileisan Pessary group increased observably (P<0.01); the number of leucocyte showed an increasing trend (P>0.05), and the numbers of granulocyte and leucocyte in positive medicine group decreased observably (P<0.01), and cervical inflammation mucosal epithelium and tissue necrosis were also signally alleviated. Conclusion Xileisan Perssary can relieve the inflammation of cervix and repair injured mucosa. It has the function of treating different diseases with the same therapy.
Objective To study the therapeutic effects of Xileisan Pessary on rats with cervicitis based on the idea of treating different diseases with the same therapy. Methods Vagina perfusion of hydroxybenzene mucilage was used to establish rat cervicitis models. Rats were randomly divided into normal group, model group, positive medicine group, low-, medium-, and high-dose Xileisan Pessary groups. Rats with cervicitis were treated with Xileisan Pessary from the next day after modeling for 10 days. The amount of neutrophilic granulocytes and leukocytes were detected by blood routine analysis meter; cervial histopathologic examination was conducted by HE staining. Results Compared with normal group, the numbers of granulocyte and leucocyte increased significantly in the model group (P<0.01). Compared with the model group, the numbers of granulocyte and leucocyte in the low-dose Xileisan Pessary group showed a decreasing trend (P<0.05, P<0.01); cervical inflammation mucosal epithelium and tissue necrosis were signally alleviated; granulocyte in the medium-dose Xileisan Pessary group showed a decreasing trend (P>0.05);the content of leucocyte hardly changed;granulocyte in the high-dose Xileisan Pessary group increased observably (P<0.01); the number of leucocyte showed an increasing trend (P>0.05), and the numbers of granulocyte and leucocyte in positive medicine group decreased observably (P<0.01), and cervical inflammation mucosal epithelium and tissue necrosis were also signally alleviated. Conclusion Xileisan Perssary can relieve the inflammation of cervix and repair injured mucosa. It has the function of treating different diseases with the same therapy.