학술논문
性激素和Treg/Th17失衡在自身免疫性肝炎中的作用及研究进展 / Progress and role of sex hormones and Treg/Th17 imbalance in autoimmune hepatitis
Document Type
Academic Journal
Author
陈玉春; 高春; 郑立婷; 李斌; 张久聪; 卢利霞; 于晓辉; CHEN Yuchun; GAO Chun; ZHENG Liting; LI Bin; ZHANG Jiucong; LU Lixia; YU Xiaohui
Source
胃肠病学和肝病学杂志 / Chinese Journal of Gastroenterology and Hepatology. 33(1):98-101
Subject
Language
Chinese
ISSN
1006-5709
Abstract
自身免疫性肝炎(autoimmune hepatitis,AIH)是一种典型的自身免疫介导的肝脏疾病,大多数患者起病隐匿,无特定的临床表现,且检出率呈逐年上升趋势.其发病机制与 T淋巴细胞介导的免疫调节紊乱,尤其是 Treg/Th17 失衡密切相关.AIH好发于围绝经期女性,性激素在免疫反应中起重要作用,其可通过影响免疫细胞的表达进而引起 AIH 的发生、发展.本文就性激素和Treg/Th17 失衡在 AIH中的作用及研究进展作一综述.
Autoimmune hepatitis(AIH)is a typical autoimmune-mediated liver disease.Most patients have insidi-ous onset without specific clinical manifestations,and the detection rate is increasing year by year.Its mechanism is re-lated to the immune regulation disorder mediated by T lymphocytes,especially the imbalance of Treg/Th17.AIH occurs mostly in perimenopausal women.Sex hormones play an important role in the immune response by affecting the expres-sion of immune cells,which can lead to the development and progression of AIH.In this paper,we briefly reviewed the role and research progress of sex hormones and Treg/Th17 imbalance in AIH.
Autoimmune hepatitis(AIH)is a typical autoimmune-mediated liver disease.Most patients have insidi-ous onset without specific clinical manifestations,and the detection rate is increasing year by year.Its mechanism is re-lated to the immune regulation disorder mediated by T lymphocytes,especially the imbalance of Treg/Th17.AIH occurs mostly in perimenopausal women.Sex hormones play an important role in the immune response by affecting the expres-sion of immune cells,which can lead to the development and progression of AIH.In this paper,we briefly reviewed the role and research progress of sex hormones and Treg/Th17 imbalance in AIH.