학술논문
热补针法联合甲氨蝶呤治疗早期类风湿关节炎的临床研究 / Clinical Study of Heat-Reinforcing Needling Combined with Methotrexate in Treatment of Early RA
Document Type
Academic Journal
Author
Source
针灸临床杂志 / Journal of Clinical Acupuncture and Moxibustion. 39(10):38-42
Subject
Language
Chinese
ISSN
1005-0779
Abstract
目的:观察热补针法联合甲氨蝶呤对早期类风湿关节炎(RA)的临床疗效.方法:64例符合诊断标准的RA患者采用随机数字表法分为热补针法组32例和西药组32例.西药组口服甲氨蝶呤片,每次5 mg,每周1次;热补针法组在西药组的基础上施加热补针法,隔日1次,每周3次.两组均治疗12周,评定两组临床疗效,治疗前后中医症状总评分、关节疾病活动指数(DAS28),检测血清C-反应蛋白(CRP)、红细胞沉降率(ESR)、类风湿因子(RF)及抗环瓜氨酸肽(CCP)抗体水平.结果:热补针法组总有效率为90.62％(29/32),高于西药组的75.00％(24/32),差异具有统计学意义(P＜0.05).两组中医症状总评分、DAS28指数、CRP、ESR、RF及抗CCP抗体水平均低于治疗前,差异具有统计学意义(P＜0.05),且热补针法组均低于西药组,差异具有统计学意义(P＜0.05).结论:热补针法联合甲氨蝶呤治疗风湿痹阻型早期类风湿关节炎疗效显著,且缩短了疗程,减少了西药的使用.
Objective:To observe clinical efficacy of heat-reinforcing needling combined with Methotrexate in treatment of early rheumatoid arthritis(RA).Methods:64 cases of early RA met the diagnostic criteria were randomly divided into the heat-reinforcing needling group(n=32)and the western medication group(n=32).The western medication group was treated with Methotrexate Tablet,5 mg,once a week;on which basis,the heat-reinforcing needling group was also treated with heat-reinforcing needling method,once every other day,three times a week.After 12 weeks of treatment,clinical efficacy was compared between the two groups.The total score of TCM symptoms and DAS28 index,as well as the contents of CRP,ESR,RF and anti-CCP antibody were detected before and after the treatment in the two groups.Results:The total effective rate was 90.62％(29/32)in the heat-reinforcing needling group,which was significantly higher than 75.00％(24/32)in the western medication group(P＜0.05).The total score of TCM symptoms,DAS28 index,as well as the levels of CRP,ESR,RF and anti-CCP antibody were significantly decreased after the treatment compared with those before the treatment(P＜0.05),which were lower in the heat-reinforcing needling group than those in the western medication group(P＜0.05).Conclusion:The combination of heat-reinforcing needling and Methotrexate has a significant therapeutic effect in treatment of early RA of wind-dampness blockage syndrome,it can shorten the course of treatment and reduce the adverse reactions of the western medication.
Objective:To observe clinical efficacy of heat-reinforcing needling combined with Methotrexate in treatment of early rheumatoid arthritis(RA).Methods:64 cases of early RA met the diagnostic criteria were randomly divided into the heat-reinforcing needling group(n=32)and the western medication group(n=32).The western medication group was treated with Methotrexate Tablet,5 mg,once a week;on which basis,the heat-reinforcing needling group was also treated with heat-reinforcing needling method,once every other day,three times a week.After 12 weeks of treatment,clinical efficacy was compared between the two groups.The total score of TCM symptoms and DAS28 index,as well as the contents of CRP,ESR,RF and anti-CCP antibody were detected before and after the treatment in the two groups.Results:The total effective rate was 90.62％(29/32)in the heat-reinforcing needling group,which was significantly higher than 75.00％(24/32)in the western medication group(P＜0.05).The total score of TCM symptoms,DAS28 index,as well as the levels of CRP,ESR,RF and anti-CCP antibody were significantly decreased after the treatment compared with those before the treatment(P＜0.05),which were lower in the heat-reinforcing needling group than those in the western medication group(P＜0.05).Conclusion:The combination of heat-reinforcing needling and Methotrexate has a significant therapeutic effect in treatment of early RA of wind-dampness blockage syndrome,it can shorten the course of treatment and reduce the adverse reactions of the western medication.