학술논문
1,8-萘二甲酰亚胺衍生物NA-17对肝癌细胞株H epG2的体外抗肿瘤作用研究 / The Anti-Tumor Mechanism of 1,8-Naphthalate Formyl Imide Derivative NA-1 7 in HepG2 Cells
Document Type
Academic Journal
Author
吴亦明; 李亮萍; 曾淑兰; 李晓红; 周祖平; 彭艳; WU Yiming; LI Liangping; ZENG Shulan; LI Xiaohong; ZHOU Zuping; PENG Yan
Source
广西师范大学学报（自然科学版） / Journal of Guangxi Normal University (Natural Science Edition). 34(3):102-108
Subject
Language
Chinese
ISSN
1001-6600
Abstract
本文对1,8-萘二甲酰亚胺衍生物NA-17(N-(3,4-亚甲二氧苯乙基)-4-(3-N,N-二甲氨基)丙胺基-1,8-萘二甲酰亚胺)在肝癌细胞中的抗肿瘤活性进行了研究。对多种肿瘤细胞的抗肿瘤活性筛选表明 NA-17对肿瘤细胞具有一定的选择性,其中对肝癌细胞(HepG2)有较好的抑制效果,但对正常肝细胞(HL-7702)毒性较低。初步的机制研究显示,NA-17通过诱发 HepG2细胞发生早期凋亡杀死 HepG2细胞,但对细胞周期无明显影响,进一步的分子机制研究表明 NA-17通过下调抗凋亡蛋白Bcl-2、Bcl-xL的表达,同时上调凋亡蛋白Bak的表达,从而诱导 HepG2细胞发生细胞凋亡。
The antitumor effects of a novel 1 ,8-naphthalate formyl imide derivative NA-1 7 in human liver cancer cells was researched.The inhibition effects of NA-1 7 in various human cancer cell lines showed that NA-17 exhibited highly selective inhibition in human liver cancer cell line HepG2,but with low toxicity to normal hepatic cell HL-7702.Preliminary research indicated that NA-17 induced apoptosis to suppress proliferation in HepG2 cells.Further studies showed that NA-17 induced the increase in the levels of Bak,while the decrease in Bcl-2 and Bcl-xL to trigger cell apoptosis.
The antitumor effects of a novel 1 ,8-naphthalate formyl imide derivative NA-1 7 in human liver cancer cells was researched.The inhibition effects of NA-1 7 in various human cancer cell lines showed that NA-17 exhibited highly selective inhibition in human liver cancer cell line HepG2,but with low toxicity to normal hepatic cell HL-7702.Preliminary research indicated that NA-17 induced apoptosis to suppress proliferation in HepG2 cells.Further studies showed that NA-17 induced the increase in the levels of Bak,while the decrease in Bcl-2 and Bcl-xL to trigger cell apoptosis.