학술논문
单胺氧化酶A基因多态性与儿童期虐待对青少年攻击行为的影响 / Association of monoamine oxidase A variable number of tandem repeats and child abuse with aggressive behavior among Chinese adolescents
Document Type
Academic Journal
Author
Source
中华精神科杂志 / Chinese Journal of Psychiatry. 47(2):84-89
Subject
Language
Chinese
ISSN
1006-7884
Abstract
目的 探讨单胺氧化酶A串联重复序列(monoamine oxidase A variable number of tandem repeats)基因多态性及儿童期虐待对中国青少年攻击行为影响.方法 采用整群随机抽样法抽取某中学637名年龄13～18岁汉族青少年样本(男388名,女249名),采用儿童创伤经历问卷评定儿童期虐待,采用儿童行为量表评定攻击行为,并从研究对象外周静脉血提取DNA进行MAOA-VNTR基因分型,采用直线回归方法检验儿童期虐待和MAOA-VNTR基因多态性各自对攻击行为的主效应及两者间的交互作用.结果 共有513名(男367名,女146名)进入研究,男性攻击行为平均得分(10.13±6.67)分,女性攻击行为平均得分(9.18 ±6.36)分,不同性别间攻击行为差异无统计学意义(P=0.08).367名男性青少年被试中,MAOA低、高活性组分别为58.3％与41.7％,且不同组间攻击行为得分差异无统计学意义(P=0.93).回归模型显示MAOA基因型对男性青少年攻击行为无预测作用,儿童期虐待经历对攻击行为有显著预测作用(P＜0.01),且MAOA基因型与不同类型童年虐待对攻击行为存在显著交互作用(MAOA×虐待总分:P ＜0.01;MAOA×躯体虐待:P=0.02;MAOA×情感虐待:P ＜0.01;MAOA×性虐待:P =0.04),MAOA低活性男性在经历儿童期躯体虐待和情感虐待后更易出现攻击倾向;146名女性青少年被试中,MAOA低活性、高活性及杂合子组分别占39.4％、22.5％和38.1％,MAOA不同基因型之间攻击行为得分差异无统计学意义(P=0.69).回归模型显示MAOA基因型对女性青少年攻击行为无预测作用,但儿童期虐待经历对其有显著预测作用(P＜0.01),且MAOA与性虐待及MAOA与情感虐待对攻击行为分别存在交互作用(P值分别为0.03和0.04),MAOA低活性女性在受到儿童期性虐待/情感虐待后更易出现攻击倾向.结论 我国13 ～18岁青少年攻击行为受到儿童期虐待经历与MAOA-VNTR基因-环境间交互作用的影响,且不同性别青少年对不同虐待类型存在敏感性差异.
Objective The association of MAOA-VNTR monoamine oxidase A variable number of tandem repeats genotype and child abuse on aggressive behavior among Chinese Han adolescents were examined.Methods A group of 513 (M:367,F:146) 13-18 years old Chinese adolescents were selected randomly,and the effects of child maltreatment [measured using the child trauma questionnaire (CTQ)]and aggressive behavior during adolescents' period [assessed by the Child Behavior Checklist for Youth SelfReport (YSR)] were examined respectively.DNA were collected and MAOA-VNTR genotype were assessed via venous blood sample.Both the main effects of MAOA genotype,children's maltreatment experience and the interaction between them were analyzed by a linear regression analysis.Results In all,513 middle school students (367 boys,146 girls) were analyzed in the study.The mean aggression scores were (10.13 ±6.67)and (9.18 ± 6.36) for boys and girls.The low and high activity of MAOA-VNTR genotype accounts for 58.3％ and 41.7％ for boys,and 39.4％ and 22.5％ for girls respectively.The GLM model showed that there were no direct association between the MAOA genotypes with aggression scores,while a significant association between children's maltreatment experience with aggressive behavior in adolescents' period were found for both boys and girls (P ＜ 0.01).Some significant interactions between MAOA genotype with subtypes of maltreatment were uncovered (boys:P =0.02,P ＜0.01 and P =0.04 for MAOA with physical abuse,emotional abuse and sexual abuse; girls:P =0.03 and P =0.04 for MAOA with sexual and emotional abuse).For adolescents with the low activity of MAOA-VNTR were more prone to commit aggressive behavior when suffered children's abuse for both gender.Conclusions Aggressive behaviors among Chinese adolescents may be affected by a gene-enviornment interaction involving MAOA-VNTR and children's abuse experience which may be differentially sensitive to the subtype of childhood maltreatment and gender.
Objective The association of MAOA-VNTR monoamine oxidase A variable number of tandem repeats genotype and child abuse on aggressive behavior among Chinese Han adolescents were examined.Methods A group of 513 (M:367,F:146) 13-18 years old Chinese adolescents were selected randomly,and the effects of child maltreatment [measured using the child trauma questionnaire (CTQ)]and aggressive behavior during adolescents' period [assessed by the Child Behavior Checklist for Youth SelfReport (YSR)] were examined respectively.DNA were collected and MAOA-VNTR genotype were assessed via venous blood sample.Both the main effects of MAOA genotype,children's maltreatment experience and the interaction between them were analyzed by a linear regression analysis.Results In all,513 middle school students (367 boys,146 girls) were analyzed in the study.The mean aggression scores were (10.13 ±6.67)and (9.18 ± 6.36) for boys and girls.The low and high activity of MAOA-VNTR genotype accounts for 58.3％ and 41.7％ for boys,and 39.4％ and 22.5％ for girls respectively.The GLM model showed that there were no direct association between the MAOA genotypes with aggression scores,while a significant association between children's maltreatment experience with aggressive behavior in adolescents' period were found for both boys and girls (P ＜ 0.01).Some significant interactions between MAOA genotype with subtypes of maltreatment were uncovered (boys:P =0.02,P ＜0.01 and P =0.04 for MAOA with physical abuse,emotional abuse and sexual abuse; girls:P =0.03 and P =0.04 for MAOA with sexual and emotional abuse).For adolescents with the low activity of MAOA-VNTR were more prone to commit aggressive behavior when suffered children's abuse for both gender.Conclusions Aggressive behaviors among Chinese adolescents may be affected by a gene-enviornment interaction involving MAOA-VNTR and children's abuse experience which may be differentially sensitive to the subtype of childhood maltreatment and gender.