학술논문
口腔硬组织修复材料仿生设计制备和临床转化 / Bionic design,preparation and clinical translation of oral hard tissue restorative materials
Document Type
Academic Journal
Author
赵菡; 卫彦; 张学慧; 杨小平; 蔡晴; 宁成云; 徐明明; 刘雯雯; 黄颖; 何颖; 郭亚茹; 江圣杰; 白云洋; 吴宇佳; 郭雨思; 郑晓娜; 李文静; 邓旭亮; ZHAO Han; WEI Yan; ZHANG Xuehui; YANG Xiaoping; CAI Qing; NING Chengyun; XU Mingming; LIU Wenwen; HUANG Ying; HE Ying; GUO Yaru; JIANG Shengjie; BAI Yunyang; WU Yujia; GUO Yusi; ZHENG Xiaona; LI Wenjing; DENG Xuliang
Source
北京大学学报(医学版) / Journal of Peking University(Health Sciences). 56(1):4-8
Subject
Language
Chinese
ISSN
1671-167X
Abstract
Oral diseases concern almost every individual and are a serious health risk to the popula-tion.The restorative treatment of tooth and jaw defects is an important means to achieve oral function and support the appearance of the contour.Based on the principle of"learning from the nature",Deng Xu-liang's group of Peking University School and Hospital of Stomatology has proposed a new concept of"microstructural biomimetic design and tissue adaptation of tooth/jaw materials"to address the worldwide problems of difficulty in treating dentine hypersensitivity,poor prognosis of restoration of tooth defects,and vertical bone augmentation of alveolar bone after tooth loss.The group has broken through the bottle-neck of multi-stage biomimetic technology from the design of microscopic features to the enhancement of macroscopic effects,and invented key technologies such as crystalline/amorphous multi-level assembly,ion-transportation blocking,and multi-physical properties of the micro-environment reconstruction,etc.The group also pioneered the cationic-hydrogel desensitizer,digital stump and core integrated restora-tions,and developed new crown and bridge restorative materials,gradient functionalisation guided tissue regeneration membrane,and electrically responsive alveolar bone augmentation restorative membranes,etc.These products have established new clinical strategies for tooth/jaw defect repair and achieved inno-vative results.In conclusion,the research results of our group have strongly supported the theoretical im-provement of stomatology,developed the technical system of oral hard tissue restoration,innovated the clinical treatment strategy,and led the progress of the stomatology industry.