학술논문
LVIS支架与EP支架辅助栓塞后交通宽颈动脉瘤的疗效及预后比较 / Comparison of efficacy and prognosis between LVIS stent and EP stent assisted embolization for communicating wide-neck aneurysms
Document Type
Academic Journal
Author
吴钟华; 龙连圣; 方文杰; 王伟; 施顺孝; 李夏良; 盛文国; WU Zhonghua; LONG Liansheng; FANG Wenjie; WANG Wei; SHI Shunxiao; LI Xialiang; SHENG Wenguo
Source
中国医药导报 / China Medical Herald. 20(35):132-135
Subject
Language
Chinese
ISSN
1673-7210
Abstract
目的 探讨LVIS支架与EP支架辅助栓塞后交通宽颈动脉瘤的疗效及预后.方法 收集2019年9月至2022年12月于湖州学院附属南太湖医院治疗的84例后交通宽颈动脉瘤患者为研究对象.根据随机数字表法将其分为LVIS组(LVIS支架)、EP组(EP支架),各42例.比较两组临床疗效、生物标志物水平、并发症发生率、预后情况.结果 随访6个月,EP组临床疗效优于LVIS组(P＜0.05).两组复发率比较,差异无统计学意义(P＞0.05).术后24 h,两组血清血管内皮生长因子(VEGF)、基质金属蛋白酶-9(MMP-9)水平均低于术前,差异有统计学意义(P＜0.05);两组术后24 h血清VEGF、MMP-9水平比较,差异无统计学意义(P＞0.05).两组并发症发生率及临床预后情况比较,差异无统计学意义(P＞0.05).结论 LVIS支架与EP支架在辅助栓塞后交通宽颈动脉瘤的疗效及预后效果相当,安全性较高,实际临床中可根据具体需求选择支架.
Objective To compare the efficacy and prognosis of stent and EP stent assisted embolization for communicating wide-neck aneurysms.Methods The clinical data of 84 patients with posterior communicating wide-neck aneurysms treated in South Taihu Hospital Affiliated to Huzhou College from September 2019 to December 2022 were collected for prospective analysis.According to the random number table method,they were divided into two LVIS group(LVIS stent)and EP group(EP stent),with 42 cases in each group.The clinical efficacy,biomarker levels,incidence of complications,and prognosis between the two groups were compared.Results After six months of follow-up,the clinical effect of EP group was better than that of LVIS group(P＜0.05).There was no significant difference in recurrence rate between the two groups(P＞0.05).24 h after operation,the levels of serum vascular endothelial growth factor(VEGF)and matrix metalloproteinase-9(MMP-9)in two groups were lower than those before operation,with statistical significance(P＜0.05).There were no significant differences in serum VEGF and MMP-9 levels between the two groups 24 h after operation(P＞0.05).There was no significant difference in the incidence of complications and clinical prognosis between the two groups(P＞0.05).Conclusion LVIS stents and EP stents have similar therapeutic and prognostic effects in assisting embolization of wide-neck aneurysms,with high safety,and stents can be selected according to specific needs in clinical practice.
Objective To compare the efficacy and prognosis of stent and EP stent assisted embolization for communicating wide-neck aneurysms.Methods The clinical data of 84 patients with posterior communicating wide-neck aneurysms treated in South Taihu Hospital Affiliated to Huzhou College from September 2019 to December 2022 were collected for prospective analysis.According to the random number table method,they were divided into two LVIS group(LVIS stent)and EP group(EP stent),with 42 cases in each group.The clinical efficacy,biomarker levels,incidence of complications,and prognosis between the two groups were compared.Results After six months of follow-up,the clinical effect of EP group was better than that of LVIS group(P＜0.05).There was no significant difference in recurrence rate between the two groups(P＞0.05).24 h after operation,the levels of serum vascular endothelial growth factor(VEGF)and matrix metalloproteinase-9(MMP-9)in two groups were lower than those before operation,with statistical significance(P＜0.05).There were no significant differences in serum VEGF and MMP-9 levels between the two groups 24 h after operation(P＞0.05).There was no significant difference in the incidence of complications and clinical prognosis between the two groups(P＞0.05).Conclusion LVIS stents and EP stents have similar therapeutic and prognostic effects in assisting embolization of wide-neck aneurysms,with high safety,and stents can be selected according to specific needs in clinical practice.