학술논문
基于主成分分析探讨偏颇体质在乳腺癌患者焦虑抑郁共病中的作用 / Discusses the Role of Biased Constitution in Comorbidity of Anxiety and Depression of Breast Cancer Patients Based on Principle Component Analysis
Document Type
Academic Journal
Author
资雨霞; 李莉; 游顶云; 张志华; 马琼; 黑春燕; 陈立敏; 李菊林; 李娅; ZI Yuxia; LI Li; YOU Dingyun; ZHANG Zhihua; MA Qiong; HEI Chunyan; CHEN Limin; LI Julin; LI Ya
Source
中国医学创新 / Medical Innovation of China. 21(1):184-188
Subject
Language
Chinese
ISSN
1674-4985
Abstract
目的:于乳腺癌患者群体中探讨偏颇体质在焦虑形成抑郁过程中的中介作用.方法:应用自制量表、中医体质量表(constitution in Chinese medicine questionnaire,CCMQ)和医院焦虑抑郁量表(hospital anxiety and depression scale,HADS)对 2019 年 7 月—2021 年 5 月选取于云南省肿瘤医院并符合纳排标准的患者进行基本信息采集、中医体质评价及焦虑抑郁状况评定.在数据标准化的基础上,对所获偏颇体质得分进行主成分分析,再进一步通过Pearson相关分析、多元线性回归模型及Bootstrap法探讨偏颇体质得分的中介作用.结果:回收有效问卷 950 份,有效回收率 90.65%.950 例患者中存在焦虑或抑郁的患者共 398 例,其中 283 例(71.11%)属于焦虑抑郁共病.8 种偏颇体质得分降维后获得一个主成分"偏颇体质得分",特征值＞1,方差贡献率为 80.13%.将其纳入Pearson相关分析后得出,偏颇体质得分与焦虑得分、抑郁得分均呈正相关(r=0.688,0.643,P＜0.001),焦虑得分与抑郁得分呈正相关(r=0.860,P＜0.001).偏颇体质在焦虑与抑郁发生间起部分中介作用,中介效应量为 0.063,总效应量为0.063+0.784=0.847,中介效应占总效应的 7.44%.结论:对焦虑患者的偏颇体质进行纠正治疗,可在一定程度上预防抑郁的发生,从而减少乳腺癌患者焦虑抑郁共病的发生率,改善其心理健康及远期预后.
Objective:To explore the mediating effect of biased constitution in the process of anxiety forming depression in breast cancer patients.Method:Self-made scale,constitution in Chinese medicine questionnaire(CCMQ)and hospital anxiety and depression scale(HADS)were used to collect basic information,evaluate TCM constitution score and assess anxiety and depression status of patients selected from Yunnan Cancer Hospital from July 2019 to May 2021 who met the inclusion and exclusion criteria.On the basis of data standardization,the principle component analysis was carried out on the obtained biased constitution scores,and the mediating effect of the biased constitution scores was further explored through Pearson correlation analysis,multiple linear regression model and Bootstrap method.Result:A total of 950 valid questionnaires were collected,and the effective recovery rate was 90.65%.Among the 950 patients,398 had anxiety or depression,of which 283(71.11%)with comorbidity of anxiety and depression.After dimensionality reduction of eight kinds of biased constitution scores,a principal component"biased constitution score"was obtained,with eigenvalue＞1 and variance contribution rate of 80.13%.After it was included in Pearson correlation analysis,the results showed that the biased constitution scores were positively correlated with anxiety scores and depression scores(r=0.688,0.643,P＜0.001),and anxiety scores was positively correlated with depression scores(r=0.860,P＜0.001).Biased constitution plays a part of mediating role between anxiety and depression,and the mediating effect was 0.063,the total effect was 0.063 + 0.784=0.847,and the mediating effect accounts for 7.44%of the total effect.Conclusion:The corrective treatment of the biased constitution of anxious patients can prevent the occurrence of depression to a certain extent,so as to reduce the incidence of comorbidity of anxiety and depression in breast cancer patients,improve their mental health and long-term prognosis.
Objective:To explore the mediating effect of biased constitution in the process of anxiety forming depression in breast cancer patients.Method:Self-made scale,constitution in Chinese medicine questionnaire(CCMQ)and hospital anxiety and depression scale(HADS)were used to collect basic information,evaluate TCM constitution score and assess anxiety and depression status of patients selected from Yunnan Cancer Hospital from July 2019 to May 2021 who met the inclusion and exclusion criteria.On the basis of data standardization,the principle component analysis was carried out on the obtained biased constitution scores,and the mediating effect of the biased constitution scores was further explored through Pearson correlation analysis,multiple linear regression model and Bootstrap method.Result:A total of 950 valid questionnaires were collected,and the effective recovery rate was 90.65%.Among the 950 patients,398 had anxiety or depression,of which 283(71.11%)with comorbidity of anxiety and depression.After dimensionality reduction of eight kinds of biased constitution scores,a principal component"biased constitution score"was obtained,with eigenvalue＞1 and variance contribution rate of 80.13%.After it was included in Pearson correlation analysis,the results showed that the biased constitution scores were positively correlated with anxiety scores and depression scores(r=0.688,0.643,P＜0.001),and anxiety scores was positively correlated with depression scores(r=0.860,P＜0.001).Biased constitution plays a part of mediating role between anxiety and depression,and the mediating effect was 0.063,the total effect was 0.063 + 0.784=0.847,and the mediating effect accounts for 7.44%of the total effect.Conclusion:The corrective treatment of the biased constitution of anxious patients can prevent the occurrence of depression to a certain extent,so as to reduce the incidence of comorbidity of anxiety and depression in breast cancer patients,improve their mental health and long-term prognosis.