학술논문
脐周八穴埋线对肥胖型多囊卵巢综合征不孕症患者IVF-ET治疗结局的影响 / Effects of Catgut Embedding Therapy at Eight Acupoints Around Umbilicus on Outcome of IVF-ET Treatment for Infertility Patients with Obese Polycystic Ovary Syndrome
Document Type
Academic Journal
Author
Source
山东中医杂志 / Shandong Journal of Traditional Chinese Medicine. 43(1):53-58
Subject
Language
Chinese
ISSN
0257-358X
Abstract
目的:探讨脐周八穴埋线治疗对肥胖型多囊卵巢综合征(PCOS)不孕症患者体外受精-胚胎移植(IVF-ET)结局的影响.方法:将90例肥胖型PCOS不孕症患者按随机数字表法分为观察组和对照组各45例.对照组患者接受IVF-ET治疗,观察组患者以脐周八穴埋线联合IVF-ET治疗,检测治疗前、后患者抑制素B(INHB)、黄体生成素(LH)、睾酮(T)、卵泡刺激素(FSH)、视黄醇结合蛋白4(RBP-4)、白脂素(Asprosin)、瘦素(LEP)、脂联素(APN)、白细胞介素-17(IL-17)、胆固醇(TC)、甘油三酯(TG)水平,以及卵巢基质血流动力学指标舒张末期流速(EDV)、收缩期最大流速(PSV)、阻力指数(RI),记录患者促性腺激素(Gn)使用剂量、获取卵泡个数、MⅡ卵率、受精率、优质胚胎率、临床妊娠率、流产率.结果:治疗后,两组患者INHB、T、LH、TC、TG、Asprosin、RBP-4、LEP、IL-17水平较治疗前降低,FSH、APN水平较治疗前升高(P＜0.05),且观察组INHB、T、LH、TC、TG、Asprosin、RBP-4、LEP、IL-17水平较对照组低,FSH、APN水平较对照组高(P＜0.05);治疗后,两组EDV、RI水平均降低,PSV水平升高(P＜0.05),且观察组EDV、RI水平较对照组低,PSV水平较对照组高(P＜0.05);观察组Gn使用剂量少于对照组(P＜0.05),获取卵泡个数多于对照组(P＜0.05),受精率、MⅡ卵率、临床妊娠率高于对照组(P＜0.05).结论:脐周八穴埋线治疗肥胖型PCOS不孕症行IVF-ET患者,可改善患者性激素指标,调节卵巢储备功能与基质血流动力学,改善糖脂代谢与胰岛素敏感性,抑制机体炎症,有利于获取卵泡,改善妊娠结局.
Objective:To investigate the effect of catgut embedding therapy at eight acupoints around the umbilicus on the outcome of in vitro fertilization-embryo transfer(IVF-ET)treatment for obese poly-cystic ovary syndrome(PCOS)infertility patients.Methods:A total of 90 obese PCOS infertility patients were divided into the observation group and the control group by using random number table method,with 45 cases in each group.The control group received IVF-ET treatment,and the observation group received catgut embedding therapy at eight acupoints around the umbilicus combined with IVF-ET treatment.Statin B(INHB),luteinizing hormone(LH),testosterone(T),follicle-stimulating hormone(FSH),retinol-binding protein 4(RBP-4),albumin(Asprosin),leptin(LEP),adiponectin(APN),interleukin-17(IL-17),cholesterol(TC),and triglyceride(TG)of patients were detected before and after treatment.End-diastolic flow rate(EDV),maximum systolic flow rate(PSV)and resistance index(RI)of ovarian stroma hemodynamic indexes were recorded.The dosage of gonadotropin(Gn),number of follicles,M Ⅱ egg rate,fertilization rate,good embryo rate,clinical pregnancy rate and abortion rate were obtained.Results:After treatment,the levels of INHB,T,LH,TC,TG,Asprosin,RBP-4,LEP and IL-17 in two groups were lower than those before treatment,while the levels of FSH and APN were higher than those before treatment(P＜0.05).The levels of INHB,T,LH,TC,TG,Asprosin,RBP-4,LEP and IL-17 in the observation group were lower than those in the control group,and the levels of FSH and APN were higher than those in the control group(P＜0.05).After treatment,EDV and RI levels were decreased and PSV level was increased in both groups(P＜0.05),and EDV and RI levels in the observation group were lower than those in the control group,while PSV level was higher than that in the control group(P＜0.05).The dose of Gn in the observation group was less than that in the con-trol group(P＜0.05),the number of follicles obtained was more than that in the control group(P＜0.05),and the fertilization rate,M Ⅱ egg rate and clinical pregnancy rate were higher than those in the control group(P＜0.05).Conclusion:Catgut embedding therapy at eight acupoints around the umbilicus of obese PCOS infertility patients undergoing IVF-ET can improve sex hormone indexes,regulate ovarian reserve function and stromal hemodynamics,improve glucose and lipid metabolism and insulin sensitivity,inhibit body inflammation,which are beneficial for patients to obtain follicles and improve the pregnancy outcomes.
Objective:To investigate the effect of catgut embedding therapy at eight acupoints around the umbilicus on the outcome of in vitro fertilization-embryo transfer(IVF-ET)treatment for obese poly-cystic ovary syndrome(PCOS)infertility patients.Methods:A total of 90 obese PCOS infertility patients were divided into the observation group and the control group by using random number table method,with 45 cases in each group.The control group received IVF-ET treatment,and the observation group received catgut embedding therapy at eight acupoints around the umbilicus combined with IVF-ET treatment.Statin B(INHB),luteinizing hormone(LH),testosterone(T),follicle-stimulating hormone(FSH),retinol-binding protein 4(RBP-4),albumin(Asprosin),leptin(LEP),adiponectin(APN),interleukin-17(IL-17),cholesterol(TC),and triglyceride(TG)of patients were detected before and after treatment.End-diastolic flow rate(EDV),maximum systolic flow rate(PSV)and resistance index(RI)of ovarian stroma hemodynamic indexes were recorded.The dosage of gonadotropin(Gn),number of follicles,M Ⅱ egg rate,fertilization rate,good embryo rate,clinical pregnancy rate and abortion rate were obtained.Results:After treatment,the levels of INHB,T,LH,TC,TG,Asprosin,RBP-4,LEP and IL-17 in two groups were lower than those before treatment,while the levels of FSH and APN were higher than those before treatment(P＜0.05).The levels of INHB,T,LH,TC,TG,Asprosin,RBP-4,LEP and IL-17 in the observation group were lower than those in the control group,and the levels of FSH and APN were higher than those in the control group(P＜0.05).After treatment,EDV and RI levels were decreased and PSV level was increased in both groups(P＜0.05),and EDV and RI levels in the observation group were lower than those in the control group,while PSV level was higher than that in the control group(P＜0.05).The dose of Gn in the observation group was less than that in the con-trol group(P＜0.05),the number of follicles obtained was more than that in the control group(P＜0.05),and the fertilization rate,M Ⅱ egg rate and clinical pregnancy rate were higher than those in the control group(P＜0.05).Conclusion:Catgut embedding therapy at eight acupoints around the umbilicus of obese PCOS infertility patients undergoing IVF-ET can improve sex hormone indexes,regulate ovarian reserve function and stromal hemodynamics,improve glucose and lipid metabolism and insulin sensitivity,inhibit body inflammation,which are beneficial for patients to obtain follicles and improve the pregnancy outcomes.