학술논문
瑞马唑仑用于亚高原人群镇静诱导的90％有效剂量研究 / Study on 90％effective dose of remimazolam for sedation induction in sub-plateau population
Document Type
Academic Journal
Author
吴婕; 张学蕊; 朱洪宽; 杨雪辉; 沈国灿; 李建钢; WU Jie; ZHANG Xuerui; ZHU Hongkuan; YANG Xuehui; SHEN Guocan; LI Jiangang
Source
云南医药 / Medicine and Pharmacy of Yunnan. 45(1):8-11
Subject
Language
Chinese
ISSN
1006-4141
Abstract
目的 探索瑞马唑仑用于亚高原人群镇静诱导的90％有效剂量.方法 选择曲靖地区长住人群中接受区域神经阻滞或椎管内麻醉择期手术的53例患者(男30例、女23例,平均年龄43.8±12.7岁),术中采用瑞马唑仑静脉注射实施镇静诱导,瑞马唑仑的初始剂量0.075 mg/kg,下1例患者采用BCD法递增剂量,剂量梯度0.025 mg/kg,最大剂量0.225 mg/kg,使用概率回归计算瑞马唑仑镇静诱导的ED90.结果 瑞马唑仑用于亚高原人群镇静诱导有效,ED90为 0.178(95％CI,1.64～0.207 mg/kg).不良反应包括6例(11.3％)低氧血症,6例(11.3％)呛咳和4例(7.5％)低血压;未发生严重不良事件.结论 瑞马唑仑用于亚高原人群镇静诱导安全有效,ED90为0.178 mg/kg.
Objective To investigate the 90％effective dose(ED90)of remimazolam for sedation induction in sub-plateau population.Methods 53 patients(30 males and 23 females,mean age 43.8±12.7 years)who received regional nerve block or intra-spinal anesthesia elective surgery were selected fromlong-term residents in Qujing area.Remimazolam intravenous injection was used to induce sedation.The initial dose of remimazolam was 0.075 mg/kg.The next patient was progressively dosed by biased coin design(BCD)method with dose gradient of 0.025 mg/kg and maximum dose of 0.225 mg/kg.Probabilistic regression was used to calculate remimazolam sedation-induced ED90.Results Remimazolam was effective in sub-plateau population with ED90 of 0.178(95％CI,1.64-0.207 mg/kg).Adverse reactions included hypoxemia in six cases(11.3％),cough in six cases(11.3％)and hypotension in four cases(7.5％).No serious adverse events occurred.Conclusions Remimazolam is safe and effective for sedation induction in sub-plateau population with ED90 of 0.178 mg/kg.
Objective To investigate the 90％effective dose(ED90)of remimazolam for sedation induction in sub-plateau population.Methods 53 patients(30 males and 23 females,mean age 43.8±12.7 years)who received regional nerve block or intra-spinal anesthesia elective surgery were selected fromlong-term residents in Qujing area.Remimazolam intravenous injection was used to induce sedation.The initial dose of remimazolam was 0.075 mg/kg.The next patient was progressively dosed by biased coin design(BCD)method with dose gradient of 0.025 mg/kg and maximum dose of 0.225 mg/kg.Probabilistic regression was used to calculate remimazolam sedation-induced ED90.Results Remimazolam was effective in sub-plateau population with ED90 of 0.178(95％CI,1.64-0.207 mg/kg).Adverse reactions included hypoxemia in six cases(11.3％),cough in six cases(11.3％)and hypotension in four cases(7.5％).No serious adverse events occurred.Conclusions Remimazolam is safe and effective for sedation induction in sub-plateau population with ED90 of 0.178 mg/kg.