학술논문
超声引导下热消融治疗尿毒症继发性甲状旁腺功能亢进症后复发的危险因素 / Risk factors of recurrence after ultrasound-guided thermal ablation for treating uremia secondary hyperparathyroidism
Document Type
Academic Journal
Author
甘剑光; 邓兆燕; 李秋林; 杨雪群; 覃莹莹; 蒋远霞; 李坚; 杨桢华; GAN Jianguang; DENG Zhaoyan; LI Qiulin; YANG Xuequn; QIN Yingying; JIANG Yuanxia; LI Jian; YANG Zhenhua
Source
中国介入影像与治疗学 / Chinese Journal of Interventional Imaging and Therapy. 20(12):735-739
Subject
Language
Chinese
ISSN
1672-8475
Abstract
目的 观察超声引导下热消融治疗尿毒症继发性甲状旁腺功能亢进症(SHPT)后复发的危险因素.方法 纳入59例接受超声引导下热消融治疗的尿毒症SHPT患者,其中23例SHPT复发(复发组)、36例未复发(未复发组);比较组间临床资料,以单因素和多因素logistic回归分析筛选复发的独立危险因素.结果 组间血清游离甲状腺素(FT4)、尿素、消融后 1天血清全段甲状旁腺激素(iPTH)、iPTH 1天下降率、最大结节最大径、消融时间、消融总能量、能量体积比及iPTH 1天下降率≤90%占比差异均有统计学意义(P均＜0.05).尿素升高、能量体积比降低及iPTH 1天下降率≤90%均为SHPT复发的独立危险因素(P均＜0.05).结论 热消融治疗尿毒症SHPT后尿素升高、能量体积比降低和iPTH 1天下降率≤90%均为其复发的独立危险因素.
Objective To observe the risk factors of recurrence after ultrasound-guided thermal ablation for treating uremia secondary hyperparathyroidism(SHPT).Methods Totally 59 patients with uremia SHPT who underwent ultrasound-guided thermal ablation were enrolled,including 23 cases with(relapse group)and 36 without SHPT recurrence(non relapsed group).Clinical data were compared between groups,univariate and multivariate logistic regression analysis were performed to screen independent risk factors of SHPT recurrence.Results There were significant differences of serum free thyroxine(FT4),urea,intact parathyroid hormone(iPTH)1 day after ablation,1 day decrease rate of iPTH,the maximum diameter of the largest nodule,ablation time,total ablation energy,energy to volume ratio and the proportion of 1 day decrease rate of iPTH≤90%between groups(all P＜0.05).Higher urea,lower energy to volume ratio and 1 day decrease rate of iPTH≤90%were all independent risk factors of SHPT recurrence(all P＜0.05).Conclusion Higher urea,lower energy to volume ratio and 1 day decrease rate of iPTH≤90%were independent risk factors of recurrence after ultrasound-guided thermal ablation for treating uremia SHPT.
Objective To observe the risk factors of recurrence after ultrasound-guided thermal ablation for treating uremia secondary hyperparathyroidism(SHPT).Methods Totally 59 patients with uremia SHPT who underwent ultrasound-guided thermal ablation were enrolled,including 23 cases with(relapse group)and 36 without SHPT recurrence(non relapsed group).Clinical data were compared between groups,univariate and multivariate logistic regression analysis were performed to screen independent risk factors of SHPT recurrence.Results There were significant differences of serum free thyroxine(FT4),urea,intact parathyroid hormone(iPTH)1 day after ablation,1 day decrease rate of iPTH,the maximum diameter of the largest nodule,ablation time,total ablation energy,energy to volume ratio and the proportion of 1 day decrease rate of iPTH≤90%between groups(all P＜0.05).Higher urea,lower energy to volume ratio and 1 day decrease rate of iPTH≤90%were all independent risk factors of SHPT recurrence(all P＜0.05).Conclusion Higher urea,lower energy to volume ratio and 1 day decrease rate of iPTH≤90%were independent risk factors of recurrence after ultrasound-guided thermal ablation for treating uremia SHPT.