학술논문
特发性嗜酸性粒细胞增多症合并静脉血栓栓塞症2例并文献复习 / Idiopathic hypereosinophilic syndrome complicated with venous thromboembolism: A report of two cases and review of literature
Document Type
Academic Journal
Author
Source
中国医刊 / Chinese Journal of Medicine. 52(5):19-23
Subject
Language
Chinese
ISSN
1008-1070
Abstract
目的 探讨特发性嗜酸性粒细胞增多症合并静脉血栓栓塞症(VTE)的临床特点与机制.方法 通过总结本院近期收治的2例及国内外文献报道确诊的9例特发性嗜酸性粒细胞增多症伴VTE患者的临床资料,分析该病的临床特点,并初步探讨其可能的发病机制.结果 本病临床表现常以VTE症状起病,同时伴有血嗜酸性粒细胞升高,血小板下降,多合并肺部浸润,激素及抗凝治疗有效.结论 特发性嗜酸性粒细胞增多症可导致高凝状态,从而引起VTE,在嗜酸性粒细胞增多症患者中应注意排除合并血栓性疾病的可能.治疗除针对血栓的抗凝治疗,联合激素治疗能有效地缓解高嗜酸性粒细胞状态.
Objective To explore the clinical features and mechanisms of idiopathic hypereosinophilic syndrome(IHES) complicated with venous thromboembolism (VTE).Methods By analyzing two recent cases of idiopathic eosinophilia combined with pulmonary embolism in our hospital and 9 cases reported in the literature,we summarized the clinical features of the disease and explored its internal relations and pathogenesis.Results The clinical manifestations of the disease often show VTE first,accompanied by elevated blood eosinophils,decreased platelets,pulmonary infiltrates,which can be treatment effectively by glucocorticoids and anticoagulant therapy.Conclusion Idiopathic hypereosinophilic syndrome can lead to a hypercoagulable status,which may result in the occurrence of VTE.As this disease is little recognized,it is quite nessesary to except the possibilty of thrombotic diseases in patients with hypereosinophilic status.Besides the treatment of thrombosis with anticoagulation drugs,glucocorticoids can effectively relieve the hypereosinophilic status.
Objective To explore the clinical features and mechanisms of idiopathic hypereosinophilic syndrome(IHES) complicated with venous thromboembolism (VTE).Methods By analyzing two recent cases of idiopathic eosinophilia combined with pulmonary embolism in our hospital and 9 cases reported in the literature,we summarized the clinical features of the disease and explored its internal relations and pathogenesis.Results The clinical manifestations of the disease often show VTE first,accompanied by elevated blood eosinophils,decreased platelets,pulmonary infiltrates,which can be treatment effectively by glucocorticoids and anticoagulant therapy.Conclusion Idiopathic hypereosinophilic syndrome can lead to a hypercoagulable status,which may result in the occurrence of VTE.As this disease is little recognized,it is quite nessesary to except the possibilty of thrombotic diseases in patients with hypereosinophilic status.Besides the treatment of thrombosis with anticoagulation drugs,glucocorticoids can effectively relieve the hypereosinophilic status.