학술논문
亚临床剂量盐酸艾司氯胺酮在剖宫产术中的效果观察 / Observation on the effect of subclinical dose of esketamine hydrochloride in cesarean section
Document Type
Academic Journal
Author
杨雪辉; 张宇; 杨春鹤; 吴婕; 韩兴忠; 李建钢; SHEN Guocan; GE Zengcai; YANG Xuehui; ZHANG Yu; YANG Chunhe; WU Jie; HAN Xingzhong; LI Jiangang
Source
云南医药 / Medicine and Pharmacy of Yunnan. 45(1):38-41
Subject
Language
Chinese
ISSN
1006-4141
Abstract
目的 探讨亚临床剂量盐酸艾司氯胺酮应用于腰硬联合麻醉剖宫产术的疗效和安全性.方法 2021年12月-2022年12月在本院接受罗哌卡因腰硬联合麻醉剖宫产术的78例孕产妇随机等分为观察组和对照组.观察组胎儿娩出后静注0.2mg/kg盐酸艾司氯胺酮,对照组静注等量生理盐水.比较麻醉指标、麻醉效果、不同时间点VAS评分、Ramsay评分和不良反应发生率的组间差异.结果 2组间麻醉指标无差异(P＞0.05);观察组麻醉优良率高于对照组,差异有统计学意义(97.44％VS 82.05％,P＜0.05);术后3h、6h、9h观察组VAS评分低于对照组,差异有统计学意义(P＜0.05)、Ramsay评分高于对照组,差异有统计学意义(P＜0.05);2组间不良反应发生率无统计学差异(10.26％VS 15.38％,P＞0.05).结论 孕产妇罗哌卡因腰硬联合麻醉剖宫产术中亚临床剂量盐酸艾司氯胺酮静注高效、安全,可增强术中、术后镇静镇痛效果,值得进一步研究和推广.
Objective To explore the efficacy and safety of subclinical doses of esketamine hydrochloride used in combined spinal-epidural anesthesia for cesarean section.Methods From December 2021 to December 2022,78 pregnant women who received ropivacaine combined spinal-epidural anesthesia for cesarean section in our hospital were randomly divided into observation group and control group.The fetuses in the observation group were intravenously injected with 0.2 mg/kg esketamine hydrochloride after delivery,while the fetuses in the control group were intravenously injected with an equal amount of normal saline.Compared the inter-group differences in anesthesia indicators,anesthesia effect,visual analogue scale(VAS)score,sedation score(Ramsay)and incidence of adverse reactions at different time points.Results There was no difference in anesthesia indicators between the two groups(all P＞0.05);the excellent and good rate of anesthesia in the observation group was higher than that in the control group(97.44％VS 82.05％,P＜0.05);The VAS scores of the observation group at 3h,6h,and 9h after surgery were lower than that in control group(mean VS mean,P＜0.05)and Ramsay score were higher than that in the control group(mean VS mean,P＜0.05);There was no statistical difference in the incidence of adverse reactions between the two groups(10.26％VS 15.38％,P＞0.05).Conclusions Ropivacaine combined spinal-epidural anesthesia during cesarean section,the intravenous injection of subclinical doses of esketamine hydrochloride is efficient and safe,and can enhance the sedative and analgesic effect during and after surgery,which is worthy of further research and promotion.
Objective To explore the efficacy and safety of subclinical doses of esketamine hydrochloride used in combined spinal-epidural anesthesia for cesarean section.Methods From December 2021 to December 2022,78 pregnant women who received ropivacaine combined spinal-epidural anesthesia for cesarean section in our hospital were randomly divided into observation group and control group.The fetuses in the observation group were intravenously injected with 0.2 mg/kg esketamine hydrochloride after delivery,while the fetuses in the control group were intravenously injected with an equal amount of normal saline.Compared the inter-group differences in anesthesia indicators,anesthesia effect,visual analogue scale(VAS)score,sedation score(Ramsay)and incidence of adverse reactions at different time points.Results There was no difference in anesthesia indicators between the two groups(all P＞0.05);the excellent and good rate of anesthesia in the observation group was higher than that in the control group(97.44％VS 82.05％,P＜0.05);The VAS scores of the observation group at 3h,6h,and 9h after surgery were lower than that in control group(mean VS mean,P＜0.05)and Ramsay score were higher than that in the control group(mean VS mean,P＜0.05);There was no statistical difference in the incidence of adverse reactions between the two groups(10.26％VS 15.38％,P＞0.05).Conclusions Ropivacaine combined spinal-epidural anesthesia during cesarean section,the intravenous injection of subclinical doses of esketamine hydrochloride is efficient and safe,and can enhance the sedative and analgesic effect during and after surgery,which is worthy of further research and promotion.