학술논문
2型糖尿病病人血清可溶性ST2与冠状动脉粥样硬化性心脏病的相关性研究 / Correlation between serum soluble ST2 and coronary atherosclerotic heart disease in patients with type 2 diabetes mellitus
Document Type
Academic Journal
Author
张玲仙; 李敏; 李辉; 张然然; 刘艳; 杨青青; 孙卫华; 时照明; 胡小磊; ZHANG Ling-xian; LI Min; LI Hui; ZHANG Ran-ran; LIU Yan; YANG Qing-qing; SUN Wei-hua; SHI Zhao-ming; HU Xiao-lei
Source
蚌埠医学院学报 / Journal of Bengbu Medical College. 48(12):1640-1644
Subject
Language
Chinese
ISSN
1000-2200
Abstract
目的:探讨2 型糖尿病(T2DM)病人血清中可溶性ST2(sST2)与冠状动脉粥样硬化性心脏病(CAD)的关系.方法:选取334 例接受冠状动脉造影(CAG)检查的病人,分成T2DM组77 例,CAD组143 例,T2DM +CAD组114 例.另选取72 名健康体检人群为对照组,收集各组的临床生化指标进行分析比较.依据Gensini评分将T2DM +CAD组分为轻度组31 例和重度组83 例.采用酶联免疫吸附法(ELISA)检测血清sST2 水平,比较各组间的sST2 水平差异并与Gensini评分进行相关性分析.结果:对照组、T2DM组、CAD组、T2DM +CAD组的各组间sST2 差异有统计学意义(P＜0.01);T2DM +CAD重度组sST2 水平高于轻度组(P＜0.05);多元线性逐步回归分析显示Gensini评分、HbA1c、LDL与血清sST2 水平呈正相关(P＜0.05～P＜0.01),HDL与血清sST2 水平呈负相关(P＜0.05);二元logistic回归分析HbA1c、sST2、Gensini评分是T2DM合并CAD的危险因素(P＜0.05～P＜0.01),HDL是T2DM合并CAD的保护因素(P＜0.01);sST2 在评估T2DM合并CAD准确性的曲线下面积为0.851,敏感性为61.4%,特异性为92.1%.结论:血清sST2 是T2DM合并CAD的危险因素;可作为评估T2DM合并CAD发生及严重程度的血清标志物.
Objective:To investigate the relationship between serum soluble ST2(sST2)and coronary atherosclerotic heart disease(CAD)in patients with type 2 diabetes mellitus(T2DM).Methods:A total of 334 patients who underwent coronary angiography were selected and divided into three groups:77 cases in T2DM group,143 cases in CAD group,and 114 cases in T2DM combined with CAD group.Seventy-two healthy people were selected as the control group during the same period.The clinical biochemical indicators of each group were collected for analysis and comparison.According to the Gensini score,the T2DM combined with CAD group was divided into mild group with 31 cases and severe group with 83 cases.Serum sST2 levels were detected by ELISA,the differences of sST2 levels among the groups were compared and the correlation analysis was performed with Gensini score.Results:There were statistically significant differences in sST2 among the control group,T2DM group,CAD group,and T2DM combined with CAD group(P＜0.01).The sST2 level in the severe group was higher than that in the mild group of T2DM combined with CAD(P＜0.05).Multivariate linear stepwise regression analysis showed that Gensini score,HbA1c,LDL were positively correlated with serum sST2 level(P＜0.05 to P＜0.01),while HDL was negatively correlated with serum sST2 level(P＜0.05).Binary logistic regression analysis showed that HbA1c,sST2,and Gensini score were risk factors for T2DM combined with CAD(P＜0.05 to P＜0.01),and HDL was a protective factor for T2DM complicated with CAD(P＜0.01).The area under the curve for the accuracy of T2DM combined with CAD was 0.851,the sensitivity was 61.4%,and the specificity was 92.1%.Conclusions:Serum sST2 is a risk factor for T2DM combined with CAD,which can be used as a serum marker to evaluate the occurrence and severity.
Objective:To investigate the relationship between serum soluble ST2(sST2)and coronary atherosclerotic heart disease(CAD)in patients with type 2 diabetes mellitus(T2DM).Methods:A total of 334 patients who underwent coronary angiography were selected and divided into three groups:77 cases in T2DM group,143 cases in CAD group,and 114 cases in T2DM combined with CAD group.Seventy-two healthy people were selected as the control group during the same period.The clinical biochemical indicators of each group were collected for analysis and comparison.According to the Gensini score,the T2DM combined with CAD group was divided into mild group with 31 cases and severe group with 83 cases.Serum sST2 levels were detected by ELISA,the differences of sST2 levels among the groups were compared and the correlation analysis was performed with Gensini score.Results:There were statistically significant differences in sST2 among the control group,T2DM group,CAD group,and T2DM combined with CAD group(P＜0.01).The sST2 level in the severe group was higher than that in the mild group of T2DM combined with CAD(P＜0.05).Multivariate linear stepwise regression analysis showed that Gensini score,HbA1c,LDL were positively correlated with serum sST2 level(P＜0.05 to P＜0.01),while HDL was negatively correlated with serum sST2 level(P＜0.05).Binary logistic regression analysis showed that HbA1c,sST2,and Gensini score were risk factors for T2DM combined with CAD(P＜0.05 to P＜0.01),and HDL was a protective factor for T2DM complicated with CAD(P＜0.01).The area under the curve for the accuracy of T2DM combined with CAD was 0.851,the sensitivity was 61.4%,and the specificity was 92.1%.Conclusions:Serum sST2 is a risk factor for T2DM combined with CAD,which can be used as a serum marker to evaluate the occurrence and severity.