학술논문
5q-综合征发病机制及治疗研究进展 / The pathogenesis and treatment of 5q - syndrome
Document Type
Academic Journal
Author
Source
徐州医科大学学报 / Acta Academiae Medicinae Xuzhou. 38(2):133-136
Subject
Language
Chinese
ISSN
1000-2065
Abstract
5号染色体长臂缺失综合征(5q-综合征)是一种造血干细胞疾病,是一种常见类型的骨髓增生异常综合征(MDS),存在于10％ 的MDS患者中.发病机制为5号染色体长臂缺失,导致部分调节造血基因单倍体功能不足.目前,雷那度胺是最为有效的治疗措施之一,但部分患者疗效不显著.本文综述近年来5q-综合征发病机制及治疗相关进展.
Chromosome 5q deletion syndrome (5q - syndrome), a hematopoietic stem cells disease is a common type of myelodysplastic syndrome (MDS), which exist in approximately 10％ -20％ of MDS patients. The pathogenesis of 5q - syndrome is the loss of chromosome 5 which leads to the lack of haploid function of hematopoietic genes. Lenalidomide is one of the most effective agent to treat 5q - syndrome, but some patients are not be well treated. This paper reviewed the pathogenesis and treatment of 5q - syndrome in recent years.
Chromosome 5q deletion syndrome (5q - syndrome), a hematopoietic stem cells disease is a common type of myelodysplastic syndrome (MDS), which exist in approximately 10％ -20％ of MDS patients. The pathogenesis of 5q - syndrome is the loss of chromosome 5 which leads to the lack of haploid function of hematopoietic genes. Lenalidomide is one of the most effective agent to treat 5q - syndrome, but some patients are not be well treated. This paper reviewed the pathogenesis and treatment of 5q - syndrome in recent years.