학술논문
骨化三醇治疗早期2型糖尿病肾病的临床效果 / Clinical effect of Calcitriol on early type 2 diabetic nephropathy
Document Type
Academic Journal
Author
Source
中国医药导报 / China Medical Herald. 20(33):92-95
Subject
Language
Chinese
ISSN
1673-7210
Abstract
目的 观察骨化三醇治疗早期 2型糖尿病肾病的临床效果.方法 选取南京医科大学第一附属医院和安徽省芜湖市第二人民医院 2019 年 8 月至 2022 年 5 月收治的 2 型糖尿病肾病患者共 90 例为研究对象,采用随机数字表法将其分为两组,各 45例.对照组在常规治疗基础上给予奥美沙坦酯治疗,观察组在对照组基础上给予骨化三醇治疗,两组疗程均为8周.比较两组治疗前后肾功能[血肌酐(Scr)、尿白蛋白与肌酐比值(UACR)、微量蛋白尿(MA)、胱抑素C(CysC)],碱性磷酸酶(ALP),血压[舒张压(DBP)、收缩压(SBP)],血糖[空腹血糖(FBG)、糖化血红蛋白(HbA1c)],NADPH氧化酶 4(NOX4)及两组疗效,不良反应发生率.结果 治疗后,两组Scr、UACR、MA、CysC及对照组ALP较治疗前下降,且观察组Scr、UACR、MA、CysC低于对照组(P＜0.05);观察组ALP较治疗前升高,且观察组高于对照组(P＜0.05).治疗后,两组SBP、DBP、FBG、HbA1c均较治疗前降低(P＜0.05),组间比较,差异无统计学意义(P＞0.05).治疗后,两组尿液NOX4较治疗前下降,且观察组低于对照组(P＜0.05).观察组疗效优于对照组(P＜0.05).两组不良反应总发生率比较,差异无统计学意义(P＞0.05).结论 骨化三醇治疗早期 2型糖尿病肾病患者能显著减轻肾功能损伤,提高疗效.
Objective To observe the clinical effect of Calcitriol on early type 2 diabetic nephropathy.Methods A total of 90 type 2 diabetic nephropathy patients admitted to the First Affiliated Hospital of Nanjing Medical University and the Wuhu Second People's Hospital from August 2019 to May 2022 were selected as the study objects,and they were divided into two groups by random number table method,with 45 cases in each group.The control group received Olmesartan Ester on the basis of conventional treatment,and the observation group received Calcitriol on the basis of the control group,the treatment course of both groups was eight weeks.Renal function(serum creatinine[Scr],urinary albumincreatinine ratio[UACR],microalbuminuria[MA],cystatin C[CysC]),alkaline phosphatase(ALP),blood pressure(diastolic blood pressure[DBP],systolic blood pressure[SBP]),blood glucose(fasting blood glucose[FBG],glycated hemoglobin[HbA 1c]),NADPH Oxidase 4(NOX4)of the two groups were compared before and after treatment,the efficacy and incidence of adverse reactions were compared between the two groups.Results After treatment,Scr,UACR,MA,CysC in both groups,and ALP in control group were lower than those before treatment,and Scr,UACR,MA,CysC in observation group were lower than those in control group(P＜0.05).The ALP in the observation group was higher than that before treatment,and the observation group was higher than that in the control group(P＜0.05).After treatment,SBP,DBP,FBG and HbA1cin both groups were decreased compared with those before treatment(P＜0.05),and there was no statistical significance between groups(P＞0.05).After treatment,urine NOX4 decreased in both groups compared with that before treatment,and the observation group was lower than the control group(P＜0.05).The efficacy of the observation group was better than that of the control group(P＞0.05).There was no significant difference in the total rate of adverse reactions between the two groups(P＞0.05).Conclusion Calcitriol in the treatment of early type 2 diabetic nephropathy patients can significantly reduce the renal function damage,the degree of interphase podocyte damage,and improve the efficacy.
Objective To observe the clinical effect of Calcitriol on early type 2 diabetic nephropathy.Methods A total of 90 type 2 diabetic nephropathy patients admitted to the First Affiliated Hospital of Nanjing Medical University and the Wuhu Second People's Hospital from August 2019 to May 2022 were selected as the study objects,and they were divided into two groups by random number table method,with 45 cases in each group.The control group received Olmesartan Ester on the basis of conventional treatment,and the observation group received Calcitriol on the basis of the control group,the treatment course of both groups was eight weeks.Renal function(serum creatinine[Scr],urinary albumincreatinine ratio[UACR],microalbuminuria[MA],cystatin C[CysC]),alkaline phosphatase(ALP),blood pressure(diastolic blood pressure[DBP],systolic blood pressure[SBP]),blood glucose(fasting blood glucose[FBG],glycated hemoglobin[HbA 1c]),NADPH Oxidase 4(NOX4)of the two groups were compared before and after treatment,the efficacy and incidence of adverse reactions were compared between the two groups.Results After treatment,Scr,UACR,MA,CysC in both groups,and ALP in control group were lower than those before treatment,and Scr,UACR,MA,CysC in observation group were lower than those in control group(P＜0.05).The ALP in the observation group was higher than that before treatment,and the observation group was higher than that in the control group(P＜0.05).After treatment,SBP,DBP,FBG and HbA1cin both groups were decreased compared with those before treatment(P＜0.05),and there was no statistical significance between groups(P＞0.05).After treatment,urine NOX4 decreased in both groups compared with that before treatment,and the observation group was lower than the control group(P＜0.05).The efficacy of the observation group was better than that of the control group(P＞0.05).There was no significant difference in the total rate of adverse reactions between the two groups(P＞0.05).Conclusion Calcitriol in the treatment of early type 2 diabetic nephropathy patients can significantly reduce the renal function damage,the degree of interphase podocyte damage,and improve the efficacy.