학술논문
帕瑞昔布钠影响老年抑郁大鼠术后认知功能的实验研究 / Paris yesterday cloth sodium influence of cognitive function after surgery for late-life depression rats experiment research
Document Type
Academic Journal
Author
Source
检验医学与临床 / Laboratory Medicine and Clinic. 14(18):2735-2802
Subject
Language
Chinese
ISSN
1672-9455
Abstract
目的 探讨帕瑞昔布钠对老年抑郁大鼠术后认知功能影响性,以期更好治疗老年抑郁症.方法 选取45只老年大鼠作为研究对象,其中15只为正常对照组,另外30只均建立手术抑郁模型,其中15只腹腔内注射0.9％氯化钠注射液,15只腹腔内注射帕瑞昔布钠,采用旷场、糖水消耗试验评估抑郁状态,采用相关检测方法观察术后认知相关指标变化情况.结果 模型组水迷宫潜伏期、空间探索时间分别为(47.84±10.56)、(20.45±5.67),帕瑞昔布钠组则分别为(39.68±6.73)、(23.45±5.89),帕瑞昔布钠组较模型组在潜伏期上下降显著,而在空间探索时间上增加显著(P＜0.05);模型组IL-1p、IL-6分别为(415.67±23.45)ng/L、(79.96±4.56)ng/L,帕瑞昔布钠组分别为(344.23±23.14)ng/L、(70.45±3.67)ng/L,帕瑞昔布钠组较模型组显著下降(P＜0.05).另外帕瑞昔布钠组则较模型组在水平运动和垂直运动上增加显著(P＜0.05),模型组在在糖水消耗、糖水偏爱上较帕瑞昔布钠组显著增加,在纯水消耗上显著减少(P＜0.05).结论 帕瑞昔布钠可通过抑制大鼠海马区炎症因子表达从而改善术后认知功能.
Objective To study parecoxib sodium in elderly postoperative cognitive function in rats of depression,and improve treatment of senile depression.Methods 45 old rats as subjects,15 were the normal control group,another 30 were established surgical model of depression in which inner 15 intraperitoneal injection of 0.9％ sodium chloride injection,intraperitoneal injection of 15 Parry celecoxib sodium,open field,sucrose consumption test were used to assess depression,correlation detection method were used to evaluate postoperative cognitive changes related indicators.Results The water maze latency,space exploration time were (47.84-±-10.56),(20.45±5.67),parecoxib sodium group were (39.68±6.73),(23.45±5.89),parecoxib sodium group compared with the model group decreased significantly in the incubation period,and in space exploration to increase the time was significantly (P＜0.05);model group,IL-1β,IL-6,respectively (415.67 ± 23.45) ng/L,(79.96 ± 4.56) ng/L,parecoxib sodium group were (344.23 ± 23.14) ng/L,(70.45 ±-3.67) ng/L,parecoxib sodium group compared with the model group decreased significantly (P＜ 0.05).Also parecoxib sodium group compared with the model group increased in the horizontal and vertical movements significantly (P＜0.05),model group in sugar consumption,a significant increase compared with the sucrose preference parecoxib sodium group,in water consumption a significant reduction(P＜0.05).Conclusion Parecoxib sodium can inhibit the expression of inflammatory cytokines in rat hippocampus to improve postoperative cognitive function.
Objective To study parecoxib sodium in elderly postoperative cognitive function in rats of depression,and improve treatment of senile depression.Methods 45 old rats as subjects,15 were the normal control group,another 30 were established surgical model of depression in which inner 15 intraperitoneal injection of 0.9％ sodium chloride injection,intraperitoneal injection of 15 Parry celecoxib sodium,open field,sucrose consumption test were used to assess depression,correlation detection method were used to evaluate postoperative cognitive changes related indicators.Results The water maze latency,space exploration time were (47.84-±-10.56),(20.45±5.67),parecoxib sodium group were (39.68±6.73),(23.45±5.89),parecoxib sodium group compared with the model group decreased significantly in the incubation period,and in space exploration to increase the time was significantly (P＜0.05);model group,IL-1β,IL-6,respectively (415.67 ± 23.45) ng/L,(79.96 ± 4.56) ng/L,parecoxib sodium group were (344.23 ± 23.14) ng/L,(70.45 ±-3.67) ng/L,parecoxib sodium group compared with the model group decreased significantly (P＜ 0.05).Also parecoxib sodium group compared with the model group increased in the horizontal and vertical movements significantly (P＜0.05),model group in sugar consumption,a significant increase compared with the sucrose preference parecoxib sodium group,in water consumption a significant reduction(P＜0.05).Conclusion Parecoxib sodium can inhibit the expression of inflammatory cytokines in rat hippocampus to improve postoperative cognitive function.