학술논문
老年失眠症患者艾司唑仑治疗前后睡眠脑电Quisi及失匹性负波观察 / AN OBSERVATIVE STUDY OF CHANGE ON QUISI AND MISMATCHING NEGATIVITY (MMN) BEFORE AND AFTER ESTAZOLAM TREATMENT IN ELDERLY PATIENTS WITH INSOMNIA
Document Type
Academic Journal
Source
现代电生理学杂志 / Journal of Modern Electrophysiology. 23(3):143-148
Subject
Language
Chinese
ISSN
1672-0458
Abstract
目的:探讨老年失眠症患者艾司唑仑治疗前后睡眠脑电(Quisi)及失匹性负波变化.方法:对64例老年失眠症患者连续进行4夜Quisi描记,其中第3、4晚上睡前予2mg艾司唑仑,观察用药后Quisi的变化.正常老人组56名,做2夜适应和基础Quisi监测.结果:(1)老年失眠症患者服用艾司唑仑后夜间Quisi显示睡眠效率提高(基线睡眠值87.5％±8.1％,第3晚服药后91.2％±7.9％,第4晚服药后91.9％±3.2％,F值5.94,P＜0.05),觉醒时间减少(同前,37.9±16.1分,28.4±7.5分,24.3±6.5分,F值7.21,P＜0.01),S1减少(同前,30.9±18.2％,24.1±11.0％,16.2±6.2％,F值8.90,P＜0.01),S2增加(同前,43.0±16.3％,59.1±17.2％,59.1±5.7％,F值7.61,P＜ 0.01),睡眠潜伏期缩短(同前,34.6±18.9分,26.9±16.5分,20.4±10.9分,F值3.95,P＜0.05). (2)与正常老人组相比,老年失眠症患者在MMN潜伏期延迟,波幅下降(P＜0.01).与此同时,P300也见同一趋势变化(P＜0.05或0.01).结论:(1)艾司唑仑不仅能改善老年患者对睡眠的主观评价,还对夜间睡眠脑电有影响. (2)我们的临床经验并建议,对普通及老年失眠症患者治疗首选艾司唑仑.