학술논문
受体酪氨酸激酶AXL在肿瘤生物学中的作用研究进展 / Research progress on the role of receptor tyrosine kinase AXL in tumor biology
Document Type
Academic Journal
Author
Source
现代肿瘤医学 / Journal of Modern Oncology. 32(1):167-171
Subject
Language
Chinese
ISSN
1672-4992
Abstract
AXL 是一种受体酪氨酸激酶(receptor tyrosine kinase,RTK),属于 TAM(TYRO3-AXL-MER)家族.在生理条件下,AXL表达于人体的心脏、骨骼肌、甲状腺中.AXL通过调控多条信号通路介导了肿瘤细胞的血管生成、迁移、侵袭、增殖与转移等过程.此外,AXL在多种癌症中高表达,对于肿瘤患者的预后评价具有重要意义,并极有可能成为一种新的诊断及预后生物标志物和治疗靶点.本文就近年来AXL在肿瘤生物学中的作用研究进展进行综述.
AXL is a receptor tyrosine kinase(RTK)belonging to the TAM(TYRO3-AXL-MER)family.Under physiological conditions,AXL is expressed in the human heart,skeletal muscle and thyroid gland.AXL mediates an-giogenesis,migration,invasion,proliferation and metastasis of tumor cells by regulating multiple signaling pathways.In addition,AXL is highly expressed in a variety of cancers,which is of great significance for the prognostic evaluation of cancer patients,and is likely to become a new diagnostic and prognostic biomarker and therapeutic target.In this pa-per,the research progress of AXL in tumor biology in recent years is reviewed.
AXL is a receptor tyrosine kinase(RTK)belonging to the TAM(TYRO3-AXL-MER)family.Under physiological conditions,AXL is expressed in the human heart,skeletal muscle and thyroid gland.AXL mediates an-giogenesis,migration,invasion,proliferation and metastasis of tumor cells by regulating multiple signaling pathways.In addition,AXL is highly expressed in a variety of cancers,which is of great significance for the prognostic evaluation of cancer patients,and is likely to become a new diagnostic and prognostic biomarker and therapeutic target.In this pa-per,the research progress of AXL in tumor biology in recent years is reviewed.