학술논문
老年分化型甲状腺癌患者术后复发转移的影响因素 / The Influencing Factors of Postoperative Recurrence and Metastasis in Elderly Patients with Differentiated Thyroid Cancer
Document Type
Academic Journal
Author
Source
实用癌症杂志 / The Practical Journal of Cancer. 39(1):110-121
Subject
Language
Chinese
ISSN
1001-5930
Abstract
目的 探究老年分化型甲状腺癌(DTC)患者术后复发转移的影响因素.方法 回顾性分析施行手术的89例老年DTC患者的病历资料,所有患者均获1年随访,将11例术后复发转移的患者设定为复发转移组,78例术后未复发转移的患者设定为未复发转移组,采用多因素Logistic回归分析老年DTC患者术后复发转移的影响因素.结果 单因素分析显示:性别、体重指数(BMI)与老年DTC患者术后复发转移无关(P＞0.05);而年龄、肿瘤直径、病理类型、TNM分期、病灶类型、术后碘治疗、术前淋巴结转移与老年DTC患者术后复发转移有关(P＜0.05).多因素Logistic回归分析显示:年龄＞75岁、滤泡状瘤、肿瘤直径≥5 cm、术后未进行碘治疗、多发病灶、术前有淋巴结转移、TNM Ⅲ～Ⅵ期为老年DTC患者术后发生复发转移的影响因素(P＜0.05).结论 年龄＞75岁、滤泡状瘤、肿瘤直径≥5 cm、术后未进行碘治疗、多发病灶、术前有淋巴结转移、TNM Ⅲ～Ⅵ期等与老年DTC患者术后复发转移联系紧密,临床对于存有上述影响因素的患者需予以高度重视,积极采取有效的预防措施,最大程度减少术后复发转移,从而改善患者预后.
Objective To explore the influencing factors of postoperative recurrence and metastasis in elderly patients with differentiated thyroid cancer(DTC).Methods A retrospective analysis was conducted on the medical records of 89 elderly DTC patients who underwent surgery.All patients were followed up for 1 year.11 patients with postoperative recurrence and me-tastasis were assigned to the recurrence and metastasis group,and 78 patients without postoperative recurrence and metastasis were assigned to the non recurrence and metastasis group.Multivariate logistic regression analysis was used to analyze the influencing factors of postoperative recurrence and metastasis in elderly DTC patients.Results Single factor analysis showed that gender,surgical method,and body mass index(BMI)were not associated with postoperative recurrence and metastasis in elderly DTC pa-tients(P＞0.05);Age,tumor diameter,pathological type,TNM staging,lesion type,postoperative iodine therapy,preoperative lymph node metastasis are associated with postoperative recurrence and metastasis in elderly DTC patients(P＜0.05).Multivari-ate logistic regression analysis showed that age＞75 years old,follicular tumor,tumor diameter≥5 cm,no postoperative iodine treatment,multiple lesions,preoperative lymph node metastasis,and TNM stage Ⅲ～Ⅵ were the influencing factors for postopera-tive recurrence and metastasis in elderly DTC patients(P＜0.05).Conclusion Age＞75 years old,follicular tumor,tumor diam-eter ≥5 cm,lack of postoperative iodine therapy,multiple lesions,preoperative lymph node metastasis,TNM stage Ⅲ～Ⅵ,etc.are closely related to postoperative recurrence and metastasis in elderly DTC patients.Patients with these influencing factors should be highly valued in clinical practice,and effective preventive measures should be taken to minimize postoperative recur-rence and metastasis,thereby improving patient prognosis.
Objective To explore the influencing factors of postoperative recurrence and metastasis in elderly patients with differentiated thyroid cancer(DTC).Methods A retrospective analysis was conducted on the medical records of 89 elderly DTC patients who underwent surgery.All patients were followed up for 1 year.11 patients with postoperative recurrence and me-tastasis were assigned to the recurrence and metastasis group,and 78 patients without postoperative recurrence and metastasis were assigned to the non recurrence and metastasis group.Multivariate logistic regression analysis was used to analyze the influencing factors of postoperative recurrence and metastasis in elderly DTC patients.Results Single factor analysis showed that gender,surgical method,and body mass index(BMI)were not associated with postoperative recurrence and metastasis in elderly DTC pa-tients(P＞0.05);Age,tumor diameter,pathological type,TNM staging,lesion type,postoperative iodine therapy,preoperative lymph node metastasis are associated with postoperative recurrence and metastasis in elderly DTC patients(P＜0.05).Multivari-ate logistic regression analysis showed that age＞75 years old,follicular tumor,tumor diameter≥5 cm,no postoperative iodine treatment,multiple lesions,preoperative lymph node metastasis,and TNM stage Ⅲ～Ⅵ were the influencing factors for postopera-tive recurrence and metastasis in elderly DTC patients(P＜0.05).Conclusion Age＞75 years old,follicular tumor,tumor diam-eter ≥5 cm,lack of postoperative iodine therapy,multiple lesions,preoperative lymph node metastasis,TNM stage Ⅲ～Ⅵ,etc.are closely related to postoperative recurrence and metastasis in elderly DTC patients.Patients with these influencing factors should be highly valued in clinical practice,and effective preventive measures should be taken to minimize postoperative recur-rence and metastasis,thereby improving patient prognosis.