학술논문
1028例过敏性皮肤病患儿过敏原特异性IgE测定及分析 / Determination and analysis of allergen specific IgE in 1 028 children with allergic dermatosis
Document Type
Academic Journal
Author
寒宇阳; 白丽霞; 李垣君; 薛慧; 张杏莲; 杨小英; Han Yuyang; Bai Lixia; Li Yuanjun; Xue Hui; Zhang Xinglian; Yang Xiaoying
Source
中国医师杂志 / Journal of Chinese Physician. 21(9):1359-1362
Subject
Language
Chinese
ISSN
1008-1372
Abstract
目的 观察过敏性皮肤病的不同过敏原特异性IgE的差异.方法 用德国Allergy Screen变应原定量免疫印迹法对1 028例过敏性皮肤病(湿疹/特应性皮炎606例,荨麻疹319例,丘疹性荨麻疹/痒疹103例)患儿过敏原特异性IgE进行检测.结果 三种过敏性皮肤病中过敏原特异性IgE阳性率差异有统计学意义(P＜0.05)的是点青/分枝/烟曲/黑曲/交链霉(x2=6.663)、牛奶(x2=10.320)、腰果(x2=14.325);不同年龄段过敏原特异性IgE阳性率差异有统计学意义(P＜0.05)的是户尘螨(x2=6.979)、猫毛皮屑(x2=9.834)、狗毛皮屑(x2=20.933)、蟑螂(x2=6.462)、点青/分枝/烟曲/黑曲/交链霉(x2 =27.119)、矮豚草/蒿/葎草/藜(x2=24.706)、鸡蛋白(x2=8.209)、牛奶(x2=38.609)、蟹(x2=6.630),其中猫毛皮屑(22.75％)、鸡蛋白(35.93％)在＜1岁阳性率高,狗毛皮屑(22.17％)、牛奶(61.82％)、蟹(3.45％)在1～3岁组阳性率高,户尘螨(10.77％)、蟑螂(3.52％)、点青/分枝/烟曲/黑曲/交链霉(21.32％)、矮豚草/蒿/葎草/藜(14.73％)在＞3岁组阳性率高;屋尘在三季度阳性率最高(17.78％)且差异有统计学意义(x2=14.443,P=0.002);湿疹/特应性皮炎不同年龄组患者过敏原特异性IgE阳性率差异有统计学意义(x2=10.204,P=0.006),1～3岁组阳性率最高.结论 不同疾病、不同年龄、不同季节过敏原种类不同,可根据疾病类型、患儿年龄及季节的不同进行个体化防治.
Objective To observe the differences in specific IgE of allergic diseases.Methods The allergens in 1 028 patients (including 606 cases of eczema/specific dermatitis,319 Cases of urticaria,103 cases of papular urticaria and prurigo) were detected by German Allergy Screen Immune mark method.Results There were statistically significant differences (P ＜ 0.05) in the positive rate of allergens among the four allergic diseases,including Penicillium notatum/ Piptocephalis/ aspergillus fumigatus/aspergillus niger/Alternaria (x2 =6.663),milk (x2 =10.320) and cashew nut (x2 =14.325);The common allergen in ＜ 1-year-old group was cat dander (22.75％),egg white (35.93％);The common allergen in 1 to 3 years old group was dog dander (22.17％),milk (61.82％) and crab (3.45％).The common allergen in ＞ 3-year-old group was dust mite (10.77％),cockroach (3.52％),Penicillium notatum/Piptocephalis/aspergillus fumigatus/aspergillus niger/Altemaria (21.32％),Short ragweed/artemisia/Humulus scandens/quinoa (14.73％).The positive rate of specific IgE against house dust in the third quarter was the highest (17.78％) and the difference was statistically significant (x2 =14.443,P =0.002).Among the statistically significant difference in the positive rate of specific IgE between eczema/atopic dermatitis in different age groups (x2 =10.204,P =0.006),the positive rate in the group of 1 to 3 years was the highest.Conclusions Different diseases,ages,and seasonal specific allergens are different,individualized treatment can be carried out according to disease types,ages and seasons.
Objective To observe the differences in specific IgE of allergic diseases.Methods The allergens in 1 028 patients (including 606 cases of eczema/specific dermatitis,319 Cases of urticaria,103 cases of papular urticaria and prurigo) were detected by German Allergy Screen Immune mark method.Results There were statistically significant differences (P ＜ 0.05) in the positive rate of allergens among the four allergic diseases,including Penicillium notatum/ Piptocephalis/ aspergillus fumigatus/aspergillus niger/Alternaria (x2 =6.663),milk (x2 =10.320) and cashew nut (x2 =14.325);The common allergen in ＜ 1-year-old group was cat dander (22.75％),egg white (35.93％);The common allergen in 1 to 3 years old group was dog dander (22.17％),milk (61.82％) and crab (3.45％).The common allergen in ＞ 3-year-old group was dust mite (10.77％),cockroach (3.52％),Penicillium notatum/Piptocephalis/aspergillus fumigatus/aspergillus niger/Altemaria (21.32％),Short ragweed/artemisia/Humulus scandens/quinoa (14.73％).The positive rate of specific IgE against house dust in the third quarter was the highest (17.78％) and the difference was statistically significant (x2 =14.443,P =0.002).Among the statistically significant difference in the positive rate of specific IgE between eczema/atopic dermatitis in different age groups (x2 =10.204,P =0.006),the positive rate in the group of 1 to 3 years was the highest.Conclusions Different diseases,ages,and seasonal specific allergens are different,individualized treatment can be carried out according to disease types,ages and seasons.