학술논문
响应面法优化二氢杨梅素口服纳米粒的制备工艺研究 / Optimization of preparation process of Dihydromyricetin oral nanoparticles by response sur?face methodology
Document Type
Academic Journal
Author
陆建媚; 黄理清; 麦琬婷; 覃裕翠; 苏晓丹; 张传政; 钟华帅; 曾勇珠; 黄秋洁; 叶勇; Lu Jianmei; Huang Liqing; Mai Wanting; Qin Yucui; Su Xiaodan; Zhang Chuanzheng; Zhong Huashuai; Zeng Yongzhu; Huang Qiujie; Ye Yong
Source
广西医科大学学报 / Journal of Guangxi Medical University. 39(8):1319-1325
Subject
Language
Chinese
ISSN
1005-930X
Abstract
目的:应用响应面法,优化二氢杨梅素纳米粒(CS-DMY-PEC-NPs)的制备工艺.方法:应用离子凝胶法制备CS-DMY-PEC-NPs,研究制备条件对纳米粒(NPs)包封率、载药量、粒径的影响,通过响应面法优化CS-DMY-PEC-NPs的制备工艺.结果:CS-DMY-PEC-NPs优化制备工艺条件为果胶(PEC)浓度2.0 mg/mL,壳聚糖(CS)的pH值4.0,离心转速为4000 r/min.在此工艺条件下制备CS-DMY-PEC-NPs的包封率为(72.07±1.61)％,载药量为(6.21±0.55)％、粒径(190.12±14.08)nm、电位(13.85±0.25)mV.结论:选用响应面法优化CS-DMY-PEC-NPs制备工艺,包封率工艺稳定、快速准确、可行,适用于该制剂的制备.