부산대학교 도서관

The use of polyphenol-based coating mechanisms has emerged as a facile and versatile method to generate multifunctional thin films for several applications including energy storage, separation, and drug delivery. The scope of this thesis is to investigate the use of two polyphenol-based mechanisms for the assembly of microcapsules for drug delivery: polydopamine and metal-phenolic networks. The mussel-inspired polydopamine has been widely studied for its adhesive and biocompatible properties. The first aspect of this thesis is to investigate the adhesion of polydopamine-coated microparticles to biological tissues. The exploitation of the simple coating mechanism onto micron-sized drug-loaded template is used to improve the retention of the drug delivery system to the target site allowing a sustained release of the therapeutics. The second aspect was to evaluate the biological effect of oligonucleotide-releasing polydopamine-coated microparticles as a tool for the investigation of the suppression of the yes-associated protein on synovial fibroblasts. The third aspect was to exploit the use of metal-phenolic networks to generate enzyme-cleavable microcapsules as endogenous stimuli-responsive drug delivery systems. The use of cell-secreted proteases could be used as a trigger for the degradation and release of therapeutic agents to the desired site. In summary, the use of two classes of polyphenol-based chemistry: polydopamine and metal-phenolic networks are investigated for their use in the biomedical field.