학술논문
Simulations of surface charge density changes during the untreated solid tumor growth
Document Type
Working Paper
Author
Prevez, Henry Bory; Jimenez, Argenis Adrian Soutelo; Oria, Eduardo José Roca; Kindelán, José Alejandro Heredia; González, Maraelys Morales; Goris, Narciso Antonio Villar; Mesa, Nibaldo Hernández; González, Victoriano Gustavo Sierra; Frometa, Yenia Infantes; Torcal, Juan Ignacio Montijano; Cabrales, Luis Enrique Bergues
Source
Subject
Language
Abstract
Understanding the untreated tumor growth kinetics and its intrinsic findings is interesting and intriguing. The aim of this study is to propose an approximate analytical expression that allows to simulate changes in surface charge density changes at cancer-surrounding healthy tissue interface during the untreated solid tumor growth. For this, the Gompertz and Poisson equations are used. Simulations reveal that the unperturbed solid tumor growth is closely related to changes in the surface charge density over time between the tumor and the surrounding healthy tissue. Furthermore, the unperturbed solid tumor growth is governed by temporal changes in this surface charge density. It is concluded that graphic strategies corroborate the correspondence between the electrical and physiological parameters in the untreated cancer, which may have an essential role in its growth, progression, metastasis and protection against immune system attack and anti-cancer therapies. In addition, the knowledge of surface charge density changes at cancer-surrounding healthy tissue interface may be relevant when redesigning the molecules in chemotherapy and immunotherapy taking into account their polarities. This can also be true in the design of completely novel therapies.
Comment: 21 pages, 3 figures. The section entitled "The main consequences of this study" was eliminated and its elements were integrated into the remaining sections of the manuscript. The order of the authors was modified. In the Introduction, new ideas were added. The section "Further comments about assumptions 1, 4 and 5" was added. New ideas were added in the Discussion
Comment: 21 pages, 3 figures. The section entitled "The main consequences of this study" was eliminated and its elements were integrated into the remaining sections of the manuscript. The order of the authors was modified. In the Introduction, new ideas were added. The section "Further comments about assumptions 1, 4 and 5" was added. New ideas were added in the Discussion