학술논문
Spectral and spatial shaping of laser-driven proton beams using a pulsed high-field magnet beamline
Document Type
Working Paper
Author
Brack, Florian-Emanuel; Kroll, Florian; Gaus, Lennart; Bernert, Constantin; Beyreuther, Elke; Cowan, Thomas E.; Karsch, Leonhard; Kraft, Stephan; Kunz-Schughart, Leoni A.; Lessmann, Elisabeth; Metzkes-Ng, Josefine; Obst-Hübl, Lieselotte; Pawelke, Jörg; Rehwald, Martin; Schlenvoigt, Hans-Peter; Schramm, Ulrich; Sobiella, Manfred; Szabó, Emília Rita; Ziegler, Tim; Zeil, Karl
Source
Subject
Language
Abstract
Intense laser-driven proton pulses, inherently broadband and highly divergent, pose a challenge to established beamline concepts on the path to application-adapted irradiation field formation, particularly for 3D. Here we experimentally show the successful implementation of a highly efficient (50% transmission) and tuneable dual pulsed solenoid setup to generate a homogeneous (8.5% uniformity laterally and in depth) volumetric dose distribution (cylindrical volume of 5 mm diameter and depth) at a single pulse dose of 0.7 Gy via multi-energy slice selection from the broad input spectrum. The experiments have been conducted at the Petawatt beam of the Dresden Laser Acceleration Source Draco and were aided by a predictive simulation model verified by proton transport studies. With the characterised beamline we investigated manipulation and matching of lateral and depth dose profiles to various desired applications and targets. Using a specifically adapted dose profile, we successfully performed first proof-of-concept laser-driven proton irradiation studies of volumetric in-vivo normal tissue (zebrafish embryos) and in-vitro tumour tissue (SAS spheroids) samples.
Comment: Submitted to Scientific Reports
Comment: Submitted to Scientific Reports