부산대학교 도서관

Epilepsy is one of the most common neurological disorders globally, affecting millions of individuals. Despite significant advancements, the precise mechanisms underlying this condition remain largely unknown, making accurately predicting and preventing epileptic seizures challenging. In this paper, we employ a bistable model, where a stable equilibrium and a stable limit cycle coexist, to describe epileptic dynamics. The equilibrium captures normal steady-state neural activity, while the stable limit cycle signifies seizure-like oscillations. The noise-driven switch from the equilibrium to the limit cycle characterizes the onset of seizures. The differences in the regions of attraction of these two stable states distinguish epileptic brain dynamics from healthy ones. We analytically construct the regions of attraction for both states. Further, using the notion of input-to-state stability, we theoretically show how the regions of attraction influence the stability of the system subject to external perturbations. Generalizing the bistable system into coupled networks, we also find the role of network parameters in shaping the regions of attraction. Our findings shed light on the intricate interplay between brain networks and epileptic activity, offering mechanistic insights into potential avenues for more predictable treatments.
Comment: 6 pages, 4 figures, submitted to IEEE CDC 2024