부산대학교 도서관

We have applied the Brouers-Sotolongo fractal kinetic equation (BSf(t,n,{\alpha})), improving notably the precision, to nine cases reported recently in the literature on drug release. The reason of using this equation is that it contains as approximations some of the mostly used empirical formula used in that field. Moreover, this equation is now successfully employed for the investigation of sorption of contaminants in aqueous media. An important extension of the BSf(t,n,{\alpha}) has been the introduction of variation of the fractal time coefficient ({\alpha}(t^{\nu} )). This improvement can lead to a greater precision of the fits and deduce some hint on the nature of the drug release process which can give precious information to propose microscopic molecular ad hoc models. We, therefore, suggest the use of the BSf(t,n,{\alpha}(t^{\nu})) formula, as a first step, in any detailed investigation and practical application of drug release data both in vitro and in vivo studies starting with the Weibull and Hill approximations to follow properly the physical solution.
Comment: original paper