부산대학교 도서관

Background and Purpose: Falling can easily lead to fractures in patients with osteoporosis, and physical function is closely related to falls. The purpose of this study was to explore the condition and the relationship between body composition and physical function in patients with osteoporosis. Methods: One hundred and sixty-four patients with osteoporosis were recruited in this study. The dual-energy X-ray absorptiometry (DXA) was used to estimate bone mineral density (BMD) and body composition (lean muscle); the physical function was assessed by grip strength (Jamar hand dynamometer) and gait speed for patients with osteoporosis. The appendicular lean mass (ALM), derived from DXA scans, is calculated by the sum of the lean muscle mass in the arms and legs and then divided by height square. Results: The number of women was about 3.7 times than the number of men; and women had lower BMDs, ALM, grip strength, and gait speed compared with men (p ＜ 0.005, 0.001, 0.001, and 0.01, respectively). The average ALMs were 5.88 ± 0.88 for women (n = 71) and 6.15 ± 1.16 kg/m^2 for men (n = 23), which was satisfied for women but insufficiency for men according to the criteria suggested by Asia Working Group for Sarcopenia (AWGS). The AWGS suggests ALM should equal or over 5.4 and 7.0 kg/m^2 for women and men, respectively. However, the ALM value of our 28.2% of women and 52.2% of men were insufficient and they would be classified as people with low muscle mass. The average grip strengths of both sex (19.28 ± 4.72 and 31.96 ± 7.36 kg for women and men, respectively) were larger than the criteria of AWGS suggested (18 and 26 kg for women and men, respectively). However, still 33.3% of women and 17.1% of men had insufficient grip strength. The average gait speed was 0.89 ± 2.70 m/s for women and 1.04 ± 0.26 m/s for men, which were quicker than the AWGS's suggestion (0.8 m/s). Similarly, it still had many women (38.1%) walking with very slow speed, while only 17.1% of men did. The grip strength was strongly correlated with ALM (r = 0.52) and moderately correlated with gait speed (r = 0.47); nevertheless, the gait speed was not well correlated with ALM (p = 0.147). Conclusion: The lean muscle mass of half of men is insufficient; and it is not uncommon that women have low grip strength and low walking speed for patients with osteoporosis. The people with large lean muscle mass are well correlated with large grip strength, while not necessary with quick gait speed. Clinical Relevance: To improve the physical function for patients with osteoporosis, we strongly suggest that emphasize on the strengthening programs, especially for women. The increasing of grip strength may also improving the gait speed after strengthening program due to they are highly correlated.