부산대학교 도서관

Background: Previous studies revealed a significant loss of microbial diversity in patients with oral squamous cell carcinoma. Oral microbiome imbalance can cause abnormal immune responses, inflammation, and infection which could affect patients' life quality and cancer occurrence. However, research on oral cancer microbiota in Taiwan remained lacking. Thus, this study aimed to explore the differences in dental plaque microbiota between patients with and without oral cancer in Taiwan. Methods: Dental plaque were collected from 15 patients with oral cancer and 15 healthy controls in Chiayi Chang Gung Memorial Hospital from October 2021 to April 2022. The Bio-information system was used to compare the 16S rRNA gene of the bacteria in the sample to confirm the bacterial phase of the sample. The statistical method was used to analyze the difference between the dental plaque microbiomes of healthy people and patients with oral cancer. Results: The species difference between dental plaque in healthy people and patients with oral cancer reached a significant level (p = 0.002), and the abundance and uniformity of dental plaque in patients with oral cancer decreased. Among them, the bacteria of Peptostreptococcus, Granulicatella, and Veillonella in the oral microbiomes of patients with oral cancer were significantly higher than those of healthy people. Conclusions: The abundance and uniformity of bacterial species significantly decreased in patients with oral cancer, while the variability between species increased.