부산대학교 도서관

BACKGROUND: MRSA is a kind of drug-resistant bacteria commonly appear in head and neck infections, and understanding its genotypes distribution will help to trace its source and formulate control strategies. The purpose of this study is to analyze and investigate the bacterial genotypes of MRSA pathogenic strains causing head and neck infections. METHODS: This prospective study analyzed the distribution of genotype proportions of MRSA strains in head and neck infections continuously collected from the Department of Laboratory Medicine, Chiayi Chang Gung Hospital during January to March 2021. Bacteria genotype testing items include Staphylococcal Cassette Chromosome mec (SCCmec), Panton-Valentine leukocidin (PVL), Multilocus Sequence Typing (MLST), and Spa type were applied to analyze and compare MRSA pathogens in head and neck, trunk and limbs, and pneumonia infections Differences in genotype. RESULTS: The total of MRSA strains in this study is 137, including 33 MRSA strains in the head and neck infection group, 60 in the pneumonia group, and 44 in the limb-trunk group. The results showed statistically significant differences between the distribution of SCCmec, MLST, and Spa type in the head and neck infection group, the pneumonia group, and the limbs and trunk group, but not between PVL (+) ratios. The MRSA between the head and neck infection group and the limbs and trunk group have high similarity in the distribution of bacterial genotypes, and a higher proportion of them may derived from community-type MRSA. CONCLUSIONS: The result of the genotype study of MRSA bacteria showed that the MRSA bacterial genes between the head and neck infection group and the limbs and trunk groups had high similarity, and a higher proportion of the source may derive from community-type MRSA, which colonization appears commonly in the nasal cavity, upper respiratory tract mucosa and skin when the patient has wounds or weaker immunity and cause opportunistic infections. The result of this study can help clinicians understand the compositions and ratios of pathogenic strains of head and neck infections and the possible sources of head and neck MRSA, which assist clinicians make diagnoses and treatments for the face of head and neck infections.