부산대학교 도서관

From 1976 to 1980, there were 85 optic neuritis patients of unknown etiology admitted at NTUH. There were 37 patients (56 eyes) accepted the follow-up examination. The examinations performed were visual acuity, pupillary reflex, fundus examination, ocular motility, diplopia, nystagmus, VEP and neurological examination. Fourteen eyes (25%) showed Gunn's pupillary reflex. Thirty-three eyes showed abnormal optic disc either as temporally pallor or totally pallor. No patient had diplopia, ocular movement disturbance or nystagmus. Twenty-three out of 37 patients accepted contrast vision and low illumination vision examinations. The result showed if the central vision decreased, the contrast and low illumination visions would decrease also. There is no definite rule to trace the ratio of decrease. There was a 46-year-old male patient having the history of right side extremities weakness and was diagnosed to be a suspicious case of multiple sclerosis. Another 28-year-old female patient was diagnosed as a probable mutiple sclerosis case. The retrograde study revealed among these 85 patients, 5 (4 females and 1 male) had been diagnosed as mutiple sclerosis, two of them died of this disease, and one had been proved by autopsy. Thirteen out of 37 patients had the visual evoked potential (VEP) examination. Nicolet CA 1000 style machine with black and white checkerboard pattern-reversal stimulus was used to cheek 21 postoptic neuritis eyes. The result showed 14 out of 21 (66.7%) were abnormal. The ratio was lower than other reports. It needs futher follow-up to get the conclusion whether the VEP change has correlation with potential multiple sclerosis.