부산대학교 도서관

Objective: Lower serum uric acid (UA) levels have been reported as a risk factor in Parkinson's disease (PD), while the results have been inconsistent. We performed a meta-analysis to evaluate the potential relationship of UA with PD. Methods: We searched in PubMed, Cochrane and Web of Science from EndNote X9 for articles published up to Nov 30, 2018. Used the following search strategy: ('uric acid' OR 'urate' OR 'hyperuricemia') AND ('Parkinson's disease' OR 'Parkinson'), while do them with the same keywords with CEPS in Taiwan. The Review Manager 5.3 was used to calculate the standardized mean differences (SMDs) with 95% CI and weights. The forest plots were drawn with MS-Excel with VBA. It means to reach the significant difference if the error bars do not cross the no effect line 0.0. Results: Nineteen studies with a total of 5310 participants (2687 PD patients and 2623 controls) were included in this meta-analysis. The current results showed that the serum UA levels in PD patients were significantly lower compared to healthy controls (SMD -0.57, 95% CI-0.74, -0.40) and these results showed no geographic regional (Asia: SMD -0.63, 95% CI -0.79, - 0.47; Non-Asia: SMD -0.25 (95% CI -0.43, - 0.07) and sex differences (men: SMD -0.68 (95% CI -0.88, -0.48); women: SMD -0.50 (95% CI -0.67, -0.34)). Conclusions: Our study showed that the UA levels are significantly lower in PD. Thus it might be a potential biomarker to indicate the risk of PD.