부산대학교 도서관

Ovarian granulosa cell tumors account for less than 5% of all ovarian tumors and more than 70% of ovarian sex cord stromal tumors. Adult granulosa cell tumors usually occur in peri-menopausal and postmenopausal women, with a peak incidence in 50-55 years of age. Juvenile granulosa cell tumors are rare tumors that account for 5% of all ovarian granulosa cell tumors and occur primarily in premenarchal girls and women younger than 30 years of age. Judging from the frequency of symptom manifestations, 97-98% of tumor symptoms are due to excessive estrogen secretion, and 2-3% are due to excessive androgen. Clinically, estrogen-producing tumors often present with amenorrhea, abnormal uterine bleeding, uterine enlargement, leiomyomas, endometrial hyperplasia, or endometrial cancer; rare virilizing symptoms include primary or secondary amenorrhea, hirsutism, clitoral hypertrophy, deep voice, muscular development, acne. In women who have already menopause or perimenopause, granulosa cell ovarian tumors may not necessarily have the typical symptoms caused by high sex hormones. They are limited by the normal physiological secretion of hormones and may not show abnormal estrogen symptoms in biochemical blood tests. Hormone concentration and high androgen may also be manifested simply in blood tests. Therefore, when ovarian tumors are combined with abnormal sex hormone values or have related symptoms caused by related hormonal abnormalities, the possibility of ovarian granulosa cell tumors should be considered in the diagnosis.