학술논문
Apomorphine所引起貓之升溫作用 / Apomorphine-Induced Hyperthermia in Cats
Document Type
Article
Author
Source
Journal of Medical Sciences / 醫學研究. Vol. 2 Issue 3, p635-642. 8 p.
Subject
Language
繁體中文
ISSN
1011-4564
Abstract
The effects of apomorphine on rectal temperature of cats were studied. Apomorphine evoked a dose-related hyperthermia which was antagonized completely by pretreatment with haloperidol in a dose of 0.5 mg/kg. Pretreatment with p-chloroamphetamine (PCA) (10-30 mg/kg daily for 3 days) significantly attenuated the hyperthermia. Results highly suggest that central dopaminergic mechanism is involved in apomorphine-induced hyperthermic effect. In addition, central serotonergic mechanism is possibly also required to elicit the hyperthermia.