부산대학교 도서관

Urease is the first crystallized protein, which dramatically changed the methodology and development of enzymologic studies. It has also been confirmed to be the first nickel dependent enzyme with a dinuclear active site, which can rapidly catalyze the hydrolysis of urea to form ammonia and carbon dioxide. Urease can be found not only in plants or soil bacteria, but also in Helicobacter Pylori, which causes gastric inflammation and severe peptic ulcer disease, and survives in the gastric mucosa of patients. Currently, scientists are attempted to prepare model complexes to mimic the dinickel active site of urease through chemical synthesis, and study the reactivity of the prepared complexes towards the hydrolysis of urea. By such investigations, we hope to further understand the hydrolytic mechanism of urea catalyzed by urease, and prove a treatment for curing peptic ulcer disease caused by Helicobacter Pylori.